PMID: 8587525Nov 1, 1995Paper

The influence of scatter on the design of optimized intensity modulations

Medical Physics
Z ChenL Reinstein

Abstract

In contrast to the traditional treatment planning process where beam parameters are adjusted in order to produce a desired dose distribution, the inverse treatment planning technique starts from the desired dose distribution and employs mathematical inversion to derive a set of optimal intensity profiles for beams with predefined directions. Crucial to the success of the inverse technique is the mathematical inversion process that yields the optimized intensity modulation. This paper systematically investigates the influence of phantom scatter in the process of designing the optimized intensity modulation and assesses its clinical consequences through the resultant treatment plans. Optimized intensity modulations and the resultant dose distributions were calculated for four prostate patients and for a simple cubic phantom under two conditions: one includes scatter and the other ignores scatter in designing the optimized intensity modulation. The effects of scatter were assessed by comparing the isodose distributions, the dose-volume histograms of the target and of the critical organs, and the tumor control probabilities and the normal tissue complication probabilities of two set prostate treatment plans. The comparison reveals ...Continue Reading

Citations

Aug 6, 2000·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M L Dirkx, B J Heijmen
May 14, 2003·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Laura HappersettGerald J Kutcher
Jul 15, 1997·International Journal of Radiation Oncology, Biology, Physics·M L DirkxP C Levendag
Apr 13, 2000·International Journal of Radiation Oncology, Biology, Physics·M L DirkxB J Heijmen
Jul 1, 1999·International Journal of Radiation Oncology, Biology, Physics·J W WongA A Martinez
Oct 11, 2002·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·D M Dimitriadis, B G Fallone
Aug 15, 2009·Zeitschrift für medizinische Physik·Klaus BratengeierMichael Flentje
Jul 23, 2003·Physics in Medicine and Biology·Qiuwen WuRadhe Mohan
Jan 26, 2011·Physics in Medicine and Biology·Yupeng LiRadhe Mohan

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