The influence of sex on right ventricular dysfunction in patients with severely depressed left ventricular ejection fraction

European Journal of Heart Failure
Manuel Martínez-SellésEulogio García

Abstract

To assess the influence of sex on right ventricular dysfunction (RVD) in patients with severe left ventricular systolic dysfunction. We studied 385 consecutive patients with left ventricular ejection fraction (LVEF) <0.35. All patients underwent invasive measurement of right ventricular and pulmonary artery pressures and evaluation of RVD by standard transthoracic echocardiography. Female patients (n=84, 21.8%) were significantly older than male patients (62.0+/-11.4 vs. 58.2+/-10.7 years), p=0.005. The prevalence of RVD was lower in women (26.5%) than in men (38.9%), p=0.03; both in patients with and without coronary artery disease (19.4% vs. 34.5% and 31.9% vs. 44.4%, respectively). Haemodynamic parameters and LVEF were similar in men and women. Low LVEF, pulmonary systolic pressure, degree of mitral regurgitation, male sex, and absence of significant coronary artery disease were independently correlated with RVD. Women with severe left ventricular systolic dysfunction have less RVD than men, despite similar haemodynamic parameters and LVEF.

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Citations

Oct 9, 2015·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·M Martínez-SellésF Fernández-Avilés
Sep 5, 2006·International Journal of Cardiology·Manuel Martínez-SellésEulogio García
Oct 8, 2009·Journal of Cardiovascular Medicine·Manuel Martínez-SellésFrancisco Fernández-Avilés
Feb 5, 2021·Frontiers in Physiology·Jennifer KeenKurt W Prins
Apr 20, 2021·Frontiers in Cardiovascular Medicine·Ana Ayesta

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