PMID: 5259754Jul 1, 1969Paper

The influence of short-range interactions on protein conformation. 3. Dipeptide distributions in proteins of known sequence and structure

Proceedings of the National Academy of Sciences of the United States of America
D KotelchuckH A Scheraga

Abstract

A statistical analysis is made of the distribution into alpha-helical and non-alpha-helical regions of the various dipeptide types appearing in a sample of seven proteins of known sequence and structure. By considering as a group all dipeptide types occurring at a given location relative to the reported helix-coil boundaries and examining the percentage of cases in which these appear in non-alpha-helical regions throughout the protein sample, we find a sharp change in the nature of the observed dipeptide types when the helix-coil boundary is crossed. Furthermore, we find that dipeptide types which occur in the coil region near the C-terminal end of helical segments are non-alpha-helical in almost 90 per cent of the cases in which they appear throughout the sample. No similar effect is found in the coil region near the N-terminal end of helical segments. These results give evidence for the importance of short-range interactions in determining protein conformation. They are also consistent with predictions based on a model for helix formation given in the second paper of this series.(1)

References

Aug 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·B W LowA D Rudko
Dec 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·D Kotelchuck, H A Scheraga
Jun 8, 1968·Nature·J DrenthB G Wolthers
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Jul 1, 1968·Biophysical Journal·P Dunnill
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Mar 4, 1967·Nature·G KarthaD Harker
Oct 14, 1967·Journal of Molecular Biology·D A Cook
Aug 1, 1964·Journal of Molecular Biology·D R DAVIES

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Citations

Jan 1, 1974·American Journal of Physical Anthropology·P E Nute, H A Pataryas
Apr 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·P N LewisH A Scheraga
Oct 23, 2004·Protein Science : a Publication of the Protein Society·Jorge A VilaHarold A Scheraga
Sep 26, 2007·Protein Science : a Publication of the Protein Society·Tamir TullerNathan Nelson
Jun 1, 1971·Archives of Biochemistry and Biophysics·P N Lewis, H A Scheraga
Sep 15, 1970·The Journal of Chemical Physics·D Aebersold, E S Pysh
Jan 1, 1976·International Journal of Peptide and Protein Research·J A BlackP Stenzel
Apr 1, 1982·International Journal of Peptide and Protein Research·P Argos, J Palau
Dec 1, 1973·Biopolymers·A W Burgess, S J Leach

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