The influence of silicone implantation on type II collagen-induced arthritis in mice

Arthritis and Rheumatism
C J SchaeferP H Wooley

Abstract

To determine whether silicone implantation exacerbates autoimmune disease in a murine experimental model of arthritis. DBA/1 mice were implanted with silicone in the form of an elastomer, gel, or oil, and immunized with type II collagen. The influence of silicone implantation on collagen-induced arthritis and the immune response to type II collagen were determined by comparison against control mice receiving sham implantation. Adjuvant effects of silicone implantation were examined by measuring cytokine levels in implanted animals and assessing autoantibodies against proteins extracted from recovered silicone implants. No adverse influence of silicone implantation on the clinical aspects of collagen-induced arthritis was observed. Further, polydimethylsiloxane silicone oil failed to serve as an adjuvant in the immune or arthritogenic response to type II collagen in mice. Cytokine analysis indicated that tumor necrosis factor alpha levels were lower and interleukin-2 levels were higher in silicone-implanted mice. The development of arthritis increased protein binding to implanted elastomers and gel, and autoantibodies against silicone-bound proteins were present in sera from arthritic mice and absent in sera from nonarthritic mi...Continue Reading

References

Jun 18, 1992·The New England Journal of Medicine·D A Kessler
Jun 18, 1992·The New England Journal of Medicine·J C Fisher
Jun 1, 1992·Clinical and Experimental Immunology·R HolmdahlR Jonsson
May 1, 1992·Annals of Plastic Surgery·A R Shons, W Schubert
Jan 1, 1988·Methods in Enzymology·P H Wooley
Dec 1, 1966·Plastic and Reconstructive Surgery·J M Andrews
Jan 1, 1984·Methods in Enzymology·C R MerrilM L Van Keuren
Jul 1, 1983·Annals of Plastic Surgery·J P HeggersT J Raine
Apr 1, 1995·Journal of Autoimmunity·E Bar-MeirM Blank
Jun 22, 1995·The New England Journal of Medicine·J Sánchez-GuerreroM H Liang
Aug 1, 1994·Seminars in Arthritis and Rheumatism·G Solomon
Aug 1, 1994·Seminars in Arthritis and Rheumatism·A J Bridges
Jan 1, 1994·Annals of Plastic Surgery·W PetersD Smith
Jun 16, 1994·The New England Journal of Medicine·S E GabrielL J Melton
Jan 1, 1996·Current Topics in Microbiology and Immunology·J O NaimC J van Oss
Oct 1, 1996·Arthritis and Rheumatism·D M Marcus

❮ Previous
Next ❯

Citations

Jul 27, 1999·Annals of the Rheumatic Diseases·C J SchaeferP H Wooley
Jan 23, 1999·Current Opinion in Rheumatology·R M Bernstein
May 21, 2016·Frontiers in Immunology·Juan-Manuel AnayaAdriana Rojas-Villarraga
Sep 17, 2013·Journal of Biomedical Materials Research. Part a·Yunpeng JiangShang-You Yang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.