The influence of smoking, gender, and family history on colorectal adenomas.

Journal of Cancer Epidemiology
Tracy OnegaLynn F Butterly

Abstract

Evidence independently links smoking, family history, and gender with increased risk of adenomatous polyps. Using data from the New Hampshire Colonoscopy Registry (2004-2006), we examined the relation of combined risk factors with adenoma occurrence in 5,395 individuals undergoing screening colonoscopy. Self-reported data on smoking, family history and other factors were linked to pathology reports identifying adenomatous polyps and modeled with multiple logistic regression. In adjusted models a >15 pack-year smoking history increased the likelihood of an adenoma (OR = 1.54, 95% CI 1.28-1.86), although </=15 pack-years did not (OR = 1.07, 95% CI 0.87-1.32). Gender-stratified models showed a significantly increased risk of adenoma at lower smoking exposure even for men (OR = 1.32; 95% CI:1.00-1.76), but not for women (OR = 0.85; 95% CI:0.61-1.14). An ordered logistic regression model of adenoma occurrence showed a smoking history of >/=15 pack-years associated with 61% higher odds of adenoma at successively larger size categories (95% CI 1.34-1.93). For individuals with a family history of colorectal cancer, smoking does not further increase the risk of adenomas. Smoking duration is linked to occurrence and size of adenoma, espe...Continue Reading

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Citations

Dec 14, 2011·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zhi-Qiang ZhaoZhi-Jun Chen
Sep 29, 2011·BMC Gastroenterology·Albert B LowenfelsDavid A Lieberman
Jun 22, 2015·Surgery·Brooke C BredbeckCarlton C Barnett
Dec 30, 2014·Cancer Causes & Control : CCC·Jane C FigueiredoJohn A Baron

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