The Influence of Some Nonsteroidal Anti-inflammatory Drugs on Metabolic Enzymes of Aldose Reductase, Sorbitol Dehydrogenase, and α-Glycosidase: a Perspective for Metabolic Disorders

Applied Biochemistry and Biotechnology
Yeliz Demirİlhami Gulçin

Abstract

Pain, as a sensible alarm signal of living organisms to avoid tissue damage, is a common and debilitating consequence of a lot of disorders and diseases. The management of chronic pain is particularly challenging. For pain treatment, many analgesic drugs are used for their therapeutic effects. In this study, some nonsteroidal anti-inflammatory drugs including etofenamate, meloxicam, diclofenac, and tenoxicam were tested against α-glycosidase from Saccharomyces cerevisiae, sorbitol dehydrogenase (SDH), and aldose reductase (AR) enzymes from sheep liver. Nonsteroidal anti-inflammatory drugs demonstrated useful inhibition properties against α-glycosidase, AR, and SDH enzymes. Ki values were found in the range of 11.93 ± 3.77-364.88 ± 40.01 μM for α-glycosidase, 3.36 ± 1.08μM-17.68 ± 3.39 mM for AR, and 1.68 ± 0.02 μM-30.98 ± 14.31 mM for SDH. They can be selective drugs as antidiabetic agents, because of their inhibitory properties against SDH, α-glycosidase, and AR enzymes.

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Citations

Feb 29, 2020·Journal of Biomolecular Structure & Dynamics·Cüneyt TürkeşŞükrü Beydemir
Mar 24, 2020·Archives of Physiology and Biochemistry·Yeliz Demir, Zeynep Köksal
May 5, 2020·Journal of Biomolecular Structure & Dynamics·Parham TaslimiIlhami Gulcin
Aug 1, 2020·Journal of Biomolecular Structure & Dynamics·Mahmoud MirzaeiSarah Mousavi
Feb 19, 2020·Anti-cancer Agents in Medicinal Chemistry·Yeliz DemirŞükrü Beydemir
Sep 13, 2020·Biotechnology and Applied Biochemistry·Fazilet Parlakova KaragözNeslihan Dikbaş
Aug 20, 2019·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Yeliz DemirMahmut Gürbüz
Aug 24, 2021·Journal of Biomolecular Structure & Dynamics·Yeliz DemirŞükrü Beydemir

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