The influence of spike rate and stimulus duration on noradrenergic neurons

Journal of Computational Neuroscience
Eric BrownG Aston-Jones

Abstract

We model spiking neurons in locus coeruleus (LC), a brain nucleus involved in modulating cognitive performance, and compare with recent experimental data. Extracellular recordings from LC of monkeys performing target detection and selective attention tasks show varying responses dependent on stimuli and performance accuracy. From membrane voltage and ion channel equations, we derive a phase oscillator model for LC neurons. Average spiking probabilities of a pool of cells over many trials are then computed via a probability density formulation. These show that: (1) Post-stimulus response is elevated in populations with lower spike rates; (2) Responses decay exponentially due to noise and variable pre-stimulus spike rates; and (3) Shorter stimuli preferentially cause depressed post-activation spiking. These results allow us to propose mechanisms for the different LC responses observed across behavioral and task conditions, and to make explicit the role of baseline firing rates and the duration of task-related inputs in determining LC response.

Citations

Jun 11, 2011·Journal of Mathematical Biology·Ali Nabi, Jeff Moehlis
May 16, 2006·Journal of Computational Neuroscience·Todd W Troyer
Sep 26, 2006·Journal of Computational Neuroscience·Juan Gao, Philip Holmes
Dec 29, 2007·Journal of Computational Neuroscience·Per DanzlJeff Moehlis
Jul 19, 2005·Annual Review of Neuroscience·Gary Aston-Jones, Jonathan D Cohen
Apr 3, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Philip EckhoffPhilip Holmes
Oct 27, 2006·Neurobiology of Disease·Kristy J BrunoEllen J Hess
Sep 1, 2005·Journal of Experimental Psychology. General·Sander NieuwenhuisJonathan D Cohen
Apr 15, 2005·Journal of Neurophysiology·Boris S GutkinAlex D Reyes
Mar 7, 2018·Translational Psychiatry·Michael J MinzenbergCameron S Carter
Feb 21, 2006·Physical Review Letters·Hideyuki Câteau, Alex D Reyes
Nov 8, 2011·Journal of Neural Engineering·Ali Nabi, Jeff Moehlis
Jan 1, 2011·SIAM Journal on Applied Dynamical Systems·Philip EckhoffPhilip Holmes
Sep 27, 2018·ACS Chemical Neuroscience·Karl T SchmidtZoé A McElligott

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