May 18, 1981

The influence of striatal stimulation and putative neurotransmitters on identified neurones in the rat substantia nigra

Brain Research
G L Collingridge, J Davies

Abstract

The response of two populations of neurones in the substantia nigra (nigro-striatal compacta neurones and reticulata neurones) to microelectrophoretically administered putative neurotransmitters and stimulation of the ipsilateral striatum has been investigated in anaesthetized rats. There were marked differences between compacta and reticulata neurones in respect to their action potential configurations, spontaneous firing rates and their responses to striatal stimulation. However, both compacta and reticulata neurones were excited and/or inhibited by striatal stimulation, although inhibition was usually the predominant response in both neuronal populations. Compacta neurones were strongly inhibited by noradrenaline (NA) and dopamine (DA) but were unaffected by acetylcholine (ACh) and 5-hydroxytryptamine (5-HT). Reticulata neurones were excited by ACh and showed mixed responses to 5-HT, DA and NA. Excitant amino acids overdepolarized compacta neurones preventing them from firing rapidly, but induced large increases in reticulata neurone firing rate; effects that were readily antagonized by D-alpha-aminoadipate. Compacta neurones were less sensitive than reticulata neurones to GABA and glycine. The action of these inhibitory ami...Continue Reading

Mentioned in this Paper

Optic Lobe, Human
Thalamic Nuclei
Neostriatum
Strychnine Assay
Neural Inhibition
Compacta
Toxin
Amino Acids, I.V. solution additive
Hemispheric Specialization
Neurons

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