The influence of structure and redox state of prenylquinones on thermotropic phase behaviour of phospholipids in model membranes

Chemistry and Physics of Lipids
M Jemioła-RzemińskaKazimierz Strzałka

Abstract

Our study was aimed to investigate the significance of the isoprenoid side chain size as well as redox state of the quinone ring for interaction of two main classes of prenylquinones: plastoquinones (PQ) and ubiquinones (UQ) with lipid bilayers. By use of differential scanning calorimetry (DSC) we have followed the thermotropic behaviour of multilamellar vesicles prepared from dipalmitoylphosphatidylcholine (DPPC) upon incorporation of increasing amount (1.3-12 mol%) of quinone (quinol) molecules. Our studies reveal that as the side chain is shorter (from 9 to 2 isoprenoid units) the height of the calorimetric profiles is reduced and the temperature of the main transition of DPPC (T(m)) decreases (T(m)=39.4 degrees C for a sample with 12 mol% of PQ-2), and then increases up to 39.8 degrees C for PQ-1. For the samples containing quinols the effect is more pronounced even at lower concentration. The greater influence of the added prenylquinones on the pretransition demonstrates a stronger distortion of the DPPC packing in the gel state. It seems that this is the isoprenoid side chain length rather than the redox state of prenylquinones that determines their effectiveness in perturbation of thermotropic properties of lipid bilayer.

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Citations

Jan 5, 2008·Photochemistry and Photobiology·Rosamaria FioriniTheodore Hazlett
Feb 22, 2012·Progress in Lipid Research·Peter J Quinn
Sep 27, 2015·Biophysical Chemistry·Willy NerdalSigne Steinkopf
Mar 9, 2005·Chemistry and Physics of Lipids·M SuwalskyK Strzałka
Apr 29, 2015·The Journal of Physical Chemistry. B·Javier HoyoFausto Sanz
Mar 17, 2015·Biochimica Et Biophysica Acta·Javier HoyoFausto Sanz
Apr 25, 2006·Biochimica Et Biophysica Acta·Yann RocheSophie Bernard
Jul 28, 2012·Journal of Colloid and Interface Science·Javier HoyoEster Guaus
Jun 18, 2017·The European Physical Journal. E, Soft Matter·Javier HoyoJuan Torrent-Burgués
Feb 10, 2007·The Journal of Physical Chemistry. B·Shuqin XiaFang Zhong

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