The Influence of Synthetic Cannabinoid UR-144 on Human Psychomotor Performance--A Case Report Demonstrating Road Traffic Risks

Traffic Injury Prevention
Piotr Adamowicz, Wojciech Lechowicz

Abstract

UR-144 [(1-pentyl-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)-methanone] is a synthetic cannabinoid, which has been detected in many "legal highs" seized from the global drug market since the beginning of 2012. It gained popularity as a "legal" alternative to classic cannabis in countries where it was not controlled. The popularity of UR-144 means that this substance is also abused by individuals driving motor vehicles. This article describes a case of driving under the influence (DUI) of UR-144. The aim of the undertaken case analysis and presenting description of pharmacological similarity of THC and UR-144 is to answer the question whether UR-144 can produce effects incompatible with safe driving. Blood from the driver was obtained by a physician approximately 2 h after the collision and 4.5 h after self-reported dosing. Police from the crash site provided behavioral observations, and the physician performed medical examination. Blood was analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). The developed method was described in detail. The method was linear in the range of 0.5-50 ng/mL; the precision and accuracy values obtained were less than 15%. The symptoms observed by police and physician who collec...Continue Reading

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Citations

Oct 21, 2015·Drug and Alcohol Dependence·Jolanta B Zawilska, Dariusz Andrzejczak
Jan 23, 2016·Forensic Toxicology·Milena MajchrzakMieczysław Sajewicz
Apr 7, 2020·Archives of Toxicology·Dino Luethi, Matthias E Liechti
Sep 8, 2017·Frontiers in Psychiatry·Aviv M WeinsteinEdythe D London
Jul 4, 2020·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Piotr Adamowicz
May 2, 2017·Journal of Analytical Toxicology·Barry K LoganMarilyn A Huestis
Mar 10, 2019·Forensic Science International : Synergy·Camille RichevalJean-Michel Gaulier

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Methods Mentioned

BETA
blood collection

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