PMID: 2097069Jan 1, 1990Paper

The influence of the athymic mutation nude on the components of the circadian rhythm of activity in mice

Chronobiology International
J BeauR Motta

Abstract

The mutation known as nude brings about the lack of a thymus gland in mice. This immunodeficiency akes it possible to graft normally unaccepted, human cancerous tumors onto the mouse. Consequently, this animal is frequently used as a model for evaluating anti-cancer therapies. The effect of this mutation on biological rhythms constitutes a necessary step before using this model for cancer chronotherapy research. We evaluated the circadian and ultradian components of the rest-activity cycle in the following strains of mice: C57BL/6 with homozygous nu/nu, heterozygous nu/+, thymectomised +/+, and sham-operated +/+. The amount of activity was reduced in nu/nu as compared to the other groups. Nonetheless, neither the nude mutation nor thymectomy yielded any notable change in the circadian rhythm of activity.

References

Apr 1, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F LéviG Mathé
Apr 5, 1985·Science·W J Hrushesky
Dec 1, 1966·Genetical Research·S P Flanagan

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Citations

Feb 2, 2013·Journal of Circadian Rhythms·Natalia PaladinoDiego A Golombek

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