PMID: 9429024Jan 16, 1998Paper

The influence of the C1-inhibitor BERINERT and the protein-free haemodialysate ACTIHAEMYL20% on the evolution of the depth of scald burns in a porcine model

Burns : Journal of the International Society for Burn Injuries
U HenzeB Klosterhalfen

Abstract

Standardized deep partial-thickness burns were inflicted on domestic pigs by scalding 30 per cent of the skin surface for 25 s with 75 degrees C hot water. The animals (n = 18; weight 25-35 kg) were divided into three groups: I, control group (n = 6), Ringer's lactate only; II, haemodialysate group (n = 6), Ringer's lactate and a protein-free haemodialysate of calf-blood (ACTIHAEMYL20%; AH) and III, C1-inhibitor group (n = 6), Ringer's lactate and C1-inhibitor (C1-INH; BERINERT). Skin biopsies were taken at defined time points (4, 28, 52 and 76 h) and investigated histologically. Depth of burn was determined morphometrically after coloration with a modified MTT-staining on frozen sections of the skin biopsies. Fluid therapy with C1-INH decelerated significantly the progression of the burn wound in the postburn-period compared to Ringer's lactate alone. In comparison with C1-INH, the treatment with AH demonstrated a less beneficial influence on the depth of scald burns. The favourable effects of C1-INH are explained by the protection of the dermal microcirculation during the acute phase of thermal injury.

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Citations

Sep 29, 2000·Critical Care Medicine·A RadkeM Kirschfink
Apr 10, 2014·Cellular and Molecular Life Sciences : CMLS·A AbdullahiM G Jeschke
May 23, 2014·International Immunology·David BraigSteffen U Eisenhardt
Jan 24, 2009·Journal of Burn Care & Research : Official Publication of the American Burn Association·Franklin van de GootHans W M Niessen
Nov 26, 2010·Journal of Burn Care & Research : Official Publication of the American Burn Association·Jeffrey W ShuppJames C Jeng
Mar 27, 2012·Journal of Burn Care & Research : Official Publication of the American Burn Association·Mark P V BegienemanPaul A J Krijnen
Jan 21, 2016·Burns : Journal of the International Society for Burn Injuries·Ara A SalibianAlan D Widgerow
Jan 25, 2013·Clinical & Developmental Immunology·Gwendolyn CazanderPeter H Nibbering
Sep 10, 2016·PloS One·Christine J AndrewsLeila Cuttle
Nov 2, 2016·Journal of Burn Care & Research : Official Publication of the American Burn Association·Hamed SadeghipourCurtis L Cetrulo
Jul 25, 2017·International Wound Journal·Christine J Andrews, Leila Cuttle
May 31, 2019·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Markus DenzingerStefanie Krajewski
Aug 12, 2014·Thrombosis and Haemostasis·Daniel SchürmannIngo Pragst
Apr 14, 2020·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Markus DenzingerAntonia Link
Aug 25, 2020·Journal of Burn Care & Research : Official Publication of the American Burn Association·Angela L F GibsonLauren T Moffatt
Sep 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dongxu LiuAlvin E Davis
Apr 28, 2017·Journal of Burn Care & Research : Official Publication of the American Burn Association·H Ibrahim KorkmazHans W M Niessen
Jul 1, 2021·Seminars in Immunopathology·Marco MannesMarkus Huber-Lang
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