PMID: 9165355May 1, 1997Paper

The influence of the cochlear efferent system on chronic acoustic trauma

Hearing Research
X Y ZhengS L McFadden

Abstract

The role of the olivocochlear bundle (OCB) in modulating noise-induced permanent injury to the auditory periphery was studied by completely sectioning the OCB fibers in chinchillas and exposing the animals while awake to a broad-band noise at 105 dB SPL for 6 h. Outer hair cell (OHC) function was assessed by measuring 2f1-f2 distortion product otoacoustic emissions (DPOAE) at frequencies from 1.2 to 9.6 kHz and cochlear microphonics (CM) at frequencies from 1 to 8 kHz. As a result of de-efferentation, the CM was decreased but the DPOAEs were unchanged in de-efferented ears as compared with efferented control and sham-operated ears. Following noise exposure, the ears that were de-efferented showed significantly more depression of DPOAE input/output functions and greater decrement of CM amplitude. The differences between de-efferented and efferent-innervated ears were evident across all the frequencies. The cochlear lesions of the OHCs reflected by traditional cytocochleograms, however, were minimal in both efferented and de-efferented ears. The results indicate that cochlear de-efferentation decreases the CM in chinchilla and increases the ear's susceptibility to noise-induced permanent hearing damage. More importantly, de-effer...Continue Reading

References

Oct 11, 1992·The Journal of the Acoustical Society of America·T A LittmanR P Bobbin
Jul 1, 1991·The Journal of the Acoustical Society of America·W Melnick
Jun 22, 1987·The Journal of Comparative Neurology·M C Brown
Feb 1, 1970·The Journal of the Acoustical Society of America·C Trahiotis, D N Elliott
Dec 1, 1966·The Journal of the Acoustical Society of America·M L Wiederhold, W T Peake
Dec 10, 1983·The Journal of Comparative Neurology·J J GuinanB E Norris
Mar 1, 1983·Hearing Research·R Rajan, B M Johnstone
Feb 1, 1982·Hearing Research·A R Cody, B M Johnstone
May 1, 1994·Hearing Research·B ScharfA Chays
Aug 1, 1996·The Journal of the Acoustical Society of America·R P HamernikS F Lei
Mar 1, 1964·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M J KARNOVSKY, L ROOTS
Dec 3, 2003·Journal of the Association for Research in Otolaryngology : JARO·Ralph H Holme, Karen P Steel
Apr 1, 1946·The Journal of Comparative Neurology·G L RASMUSSEN
Nov 28, 2013·Audiology & Neuro-otology·Stephan WolpertWolfgang Wagner

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Citations

Jun 5, 2003·Journal of the Association for Research in Otolaryngology : JARO·E Christopher Kirk, David W Smith
Nov 9, 2010·Journal of the Association for Research in Otolaryngology : JARO·Jinsheng ZhangXueguo Zhang
Nov 16, 2002·Hearing Research·Anneliese Schrott-FischerMichel Eybalin
Aug 10, 2002·Clinical Otolaryngology and Allied Sciences·D M BaguleyD A Moffat
Oct 6, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stéphane F MaisonM Charles Liberman
Sep 23, 2014·The Journal of the Acoustical Society of America·Anne E LuebkeBrenda L Lonsbury-Martin
Jan 17, 2007·Hearing Research·Asa SkjönsbergDavid F Dolan
Nov 10, 2006·Hearing Research·Eric C Bielefeld, Donald Henderson
Apr 29, 2010·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Jeffrey A MarlerFrederic L Wightman
Apr 23, 1999·The Journal of the Acoustical Society of America·C AbdalaY S Sininger
Apr 19, 2017·Archives of Environmental & Occupational Health·Maria Valeria RosatiAngela Sancini
Nov 9, 2000·Microscopy Research and Technique·R B IllingS A Michler
Sep 28, 1998·The European Journal of Neuroscience·K C HornerY Cazals
May 12, 2001·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·G De CeulaerP J Govaerts
Aug 8, 2007·International Journal of Audiology·Wayne J WilsonAndrea Kelly
Jan 10, 2002·Audiology : Official Organ of the International Society of Audiology·N QuarantaS Di Girolamo
Nov 26, 2008·Journal of Basic and Clinical Physiology and Pharmacology·Joseph AttiasDoron Gothelf
Apr 1, 1999·The Journal of Comparative Neurology·X Y ZhengR J Salvi
Aug 13, 1999·Journal of Neurophysiology·S G Kujawa, M C Liberman
Nov 8, 2001·Journal of Neurophysiology·M C Brown
Jun 2, 2021·The European Journal of Neuroscience·Konstantin TziridisHolger Schulze
Jul 9, 2021·Clinical Neurophysiology Practice·H FujihiraM Kashino

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