The influence of the Great East Japan earthquake on microscopic polyangiitis: A retrospective observational study

PloS One
Yoichi TakeuchiTasuku Nagasawa

Abstract

Antineutrophil cytoplasmic antibody-associated vasculitis is triggered by environmental factors, including silica dust exposure. Repeated tsunami waves brought a large volume of silica-containing sludge inland after the Great East Japan earthquake in 2011. We aimed to determine if the serious disaster influenced the clinical features of the microscopic polyangiitis. This is an observational retrospective study conducted in a single institute. A total of 43 patients were included based on the CHCC2012 criteria for microscopic polyangiitis from 2007 to 2015. We used the Poisson regression model to determine the incidence of microscopic polyangiitis within the annual population of the medical district. The participants were selected during a 3-year period from before (N = 13) to after the disaster (N = 20). The differences of parameters and the overall survival between the groups were analyzed. The incidence of microscopic polyangiitis increased after the disaster (λ = 17.4/million/year [95%CI: 7.66-39.6] before the disaster and λ = 33.1/million/year [17.7-61.7] after the disaster, P = 0.044). A high Birmingham Activity Score was associated with a high incidence of microscopic polyangiitis after the disaster. The overall survival ...Continue Reading

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Citations

Dec 28, 2017·Internal Medicine·Yoshie OjimaTasuku Nagasawa
Feb 2, 2020·European Journal of Internal Medicine·Fernando Salvador
Apr 30, 2021·Journal of Translational Autoimmunity·Daisuke TsukuiHajime Kono
Jan 7, 2022·Journal of Nephrology·Devan MakatiDinesh Kannabhiran

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Methods Mentioned

BETA
biopsy
ELISA
biopsies
bronchoalveolar lavage
electron

Software Mentioned

EZR
R
GEJE

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