The influence of the individual neuropsychiatric symptoms of people with Alzheimer disease on family caregiver distress-A longitudinal ALSOVA study

International Journal of Geriatric Psychiatry
Ilona HallikainenTarja H Välimäki

Abstract

Family caregivers (FCs) face a variety of demands while caring for persons with Alzheimer disease (AD). Longitudinal studies identifying the specific AD-related neuropsychiatric symptoms (NPS) that contribute to FC distress are rare. We analyzed which NPS in association with care recipient and caregiver demographic factors are associated with FC psychological distress over a 36-month follow-up period. This is a longitudinal study with annual follow-up. Participants were people with AD (n = 226) and their FCs (n = 226). The Neuropsychiatric Inventory was used to assess NPS, and The General Health Questionnaire was used as a measure of caregiver distress. The effect of NPS on FC psychological distress over time was analyzed using a linear-mixed effect model. Delusions (P = .003), agitation (P < .001), and sleep disturbance (P = .005) are associated with FC psychological distress. One of four people with AD developed delusions and agitation during the early stages of the disease. Sleep disturbances increased over the follow-up time. A marital relationship was associated with FC distress, while some prevalent symptoms, such as depression, did not affect distress. Delusions, agitation, and sleep disturbances may cause distress to th...Continue Reading

References

Feb 1, 1979·Psychological Medicine·D P Goldberg, V F Hillier
Oct 19, 2000·Psychological Medicine·U WernekeB T Ustün
Feb 7, 2003·International Journal of Geriatric Psychiatry·Marjolein E de VugtFrans R J Verhey
Feb 15, 2007·Dementia and Geriatric Cognitive Disorders·Naomi MatsumotoHirotaka Tanabe
Feb 26, 2008·Aging & Mental Health·E Moniz-CookUNKNOWN INTERDEM group
Apr 9, 2013·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Yonas E GedaUNKNOWN Neuropsychiatric Syndromes Professional Interest Area of ISTAART
Jan 11, 2014·American Journal of Alzheimer's Disease and Other Dementias·José María García-AlbercaAlmudena Lara
May 13, 2015·International Journal of Geriatric Psychiatry·Caroline L SutcliffeDavid J Challis
Aug 26, 2015·Dementia and Geriatric Cognitive Disorders·Thais Bento Lima-SilvaMônica Sanches Yassuda
Sep 10, 2015·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Tarja H VälimäkiAnne M Koivisto
Nov 21, 2015·Aging & Mental Health·Jacqueline van der LeeRose-Marie Dröes
Feb 19, 2016·International Journal of Geriatric Psychiatry·Alexandra FeastEsme Moniz-Cook
Jul 15, 2016·Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society·Michele TorrisiRocco S Calabrò
Mar 21, 2017·International Journal of Geriatric Psychiatry·Toril Marie TerumIngelin Testad
Mar 23, 2017·The Gerontologist·Ari VoutilainenTarja Välimäki
Oct 27, 2017·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Krista L LanctôtBrendon Boot
Jan 30, 2018·Journal of Alzheimer's Disease : JAD·Ilona HallikainenAnne M Koivisto

❮ Previous
Next ❯

Citations

Aug 18, 2020·Journal of Alzheimer's Disease : JAD·Robin van den KieboomInge Bongers
Oct 17, 2019·Frontiers in Pharmacology·Reena T Gottesman, Yaakov Stern
Feb 18, 2020·Current Alzheimer Research·Lisa GadomskyKristina Endres
Apr 13, 2021·International Journal of Mental Health Nursing·Jenny Jia Yu, Edwina Holbeach
Apr 27, 2021·Journal of Alzheimer's Disease : JAD·Reena T GottesmanYian Gu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.