The influence of the leaflets' curvature on the flow field in two bileaflet prosthetic heart valves

Journal of Biomechanics
Mauro GrigioniVincenzo Barbaro

Abstract

A successful mechanical prosthetic heart valve design is the bileaflet valve, which has been implanted for the first time more than 20 years ago. A key feature of bileaflet valves is the geometry of the two leaflets, which can be very important in determining the flow field. Laser Doppler anemometry (LDA) was used to perform an accurate study of the velocity and turbulence shear stress peak values (TSS(max)) fields at four distances from the valve plane. TSS(max) is a relevant parameter to assess the risk of hemolysis and platelet activation associated to the implantation of a prosthetic device, continuously interacting with blood. Two bileaflet valves were tested: the St. Jude HP and the Sorin Bicarbon, of the same nominal size (19mm). The former has flat leaflets, whereas the latter's leaflets have a cylindrical surface. A high regime (CO: 6l/min) was imposed, in order to test the two valves at maximum Reynolds number and consequent turbulence generation. The flat-leaflet design of the St. Jude generates a TSS field constant with distance; on the contrary, the Bicarbon's shear stress field undergoes an evident development, with an unexpected central peak at a distance comparable to the valve's dimensions (21mm). The two bilea...Continue Reading

References

Jul 1, 1992·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·F VallanaA Piwnica
Jan 1, 1992·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·R T JohnstonT J Spyt
Oct 1, 1974·Circulation Research·P D Stein, H N Sabbah
Jul 1, 1982·The Annals of Thoracic Surgery·L H Edmunds
Jan 1, 1995·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·J Fisher
May 1, 1996·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·A A FontaineA P Yoganathan

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Citations

Jun 19, 2009·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Hwansung LeeTakao Yamamoto
Oct 3, 2007·Annals of Biomedical Engineering·Abdulhameed AzizWayne R Curtis
Dec 1, 2007·Annals of Biomedical Engineering·Liang GeAjit P Yoganathan
Jun 4, 2011·Annals of Biomedical Engineering·Alessandro Bellofiore, Nathan J Quinlan
Feb 5, 2004·The Annals of Thoracic Surgery·Nicola VitaleLuigi de Luca Tupputi Schinosa
Aug 19, 2008·Medical Engineering & Physics·O SmadiL Kadem
Apr 4, 2015·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Mehdi JahandardoostHadi Mohammadi
Jun 13, 2009·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Hwansung LeeYoshiyuki Taenaka
Jul 8, 2010·Cardiovascular Engineering and Technology·Krishnan B Chandran
Jun 2, 2005·Artificial Organs·Jingchun WuBradley E Paden
Jan 5, 2002·Journal of Clinical Laser Medicine & Surgery
Feb 27, 2003·The International Journal of Artificial Organs·M GrigioniV Barbaro
Jul 27, 2017·Medical & Biological Engineering & Computing·Mohamad Shukri ZakariaKamarul Arifin Ahmad
Mar 8, 2002·The Journal of Thoracic and Cardiovascular Surgery·Gianclaudio MecozziUberto Bortolotti

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