The influence of the pattern of mandibular invasion on recurrence and survival in oral squamous cell carcinoma

Head & Neck
Richard J ShawE David Vaughan

Abstract

Controversy exists over the predictive value of the presence and pattern of tumor invasion of the mandible in oral squamous cell carcinoma (SCC). Many authors have questioned increasing the classification of small tumors to T4 on the basis of mandibular invasion alone. There are little data on the influence of the pattern of invasion on prognosis. We prospectively reviewed 100 consecutive mandibular resections for previously untreated oral SCC. Clinical and pathologic data collected included details of soft and hard tissue histologic findings. Outcomes included recurrence (local, regional, and distant metastases), disease-specific survival, and death from other causes. The median follow-up for survivors was 65 months. Of 100 cases, 65 involved segmental and 35 involved marginal resections. Sixty-two percent of mandibles were invaded by tumor. Local recurrence occurred in 21% and was strongly correlated with tumor size, nodal involvement, and pattern of soft tissue invasion. The 5-year disease-specific survival was 68%, and the crude survival was 50%. Mandibular invasion predicted for recurrence and disease-specific survival, even after correcting for the effects of other variables. The pattern of mandibular invasion (erosive/in...Continue Reading

References

Feb 1, 1978·Plastic and Reconstructive Surgery·S Poleksic, H J Kalwaic
Feb 1, 1989·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·P J Slootweg, H Müller
May 1, 1997·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·R A OrdJ Papadimitrou
Jun 1, 1997·Clinical Otolaryngology and Allied Sciences·A S JonesT Karkanevatos
Jan 26, 2000·The Laryngoscope·R J WongM A Varvares
Nov 21, 2000·Head & Neck·C S AshM A Cohen
Jul 24, 2001·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·D GomezJ Pinsolle
Aug 15, 2002·The British Journal of Oral & Maxillofacial Surgery·J S BrownJ A Woolgar
Feb 5, 2004·International Journal of Oral and Maxillofacial Surgery·C J O'BrienG D Parker

❮ Previous
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Citations

Feb 16, 2010·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Eric M GendenAlessandra Rinaldo
May 28, 2005·International Journal of Oral and Maxillofacial Surgery·J BrownD Vaughan
Jan 13, 2010·American Journal of Clinical Oncology·Ly DoNayana Vora
Feb 27, 2009·Future Oncology·Julia A Woolgar, Gillian L Hall
Mar 5, 2008·Dento Maxillo Facial Radiology·D TrikeriotisD Nikolaou
Apr 1, 2010·Journal of Cancer Research and Clinical Oncology·Thomas MückeMarco Kesting
Sep 20, 2012·Oral Oncology·Xiaoyi ZhangKeith L Kirkwood
Jul 10, 2012·Biochemical and Biophysical Research Communications·Erika OueAkira Yamaguchi
Dec 14, 2011·Oral Oncology·Jörg HandschelKarl Christoph Sproll
Aug 23, 2011·Surgical Oncology·Latha P RaoManoj Pandey
Oct 2, 2009·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·M PandeyM Shukla
Jan 7, 2009·The British Journal of Oral & Maxillofacial Surgery·Cyrus J Kerawala
Dec 5, 2008·The British Journal of Oral & Maxillofacial Surgery·R J ShawS N Rogers
Aug 5, 2008·Oral Oncology·Simon N RogersDavid Vaughan
Jun 15, 2007·The British Journal of Oral & Maxillofacial Surgery·Richard J ShawJanet M Risk
Feb 28, 2008·The Laryngoscope·Rajan S PatelChristopher J O'Brien
Jul 26, 2011·Periodontology 2000·Richard J ShawChris Butterworth
Jul 26, 2011·Periodontology 2000·Julia A Woolgar, Asterios Triantafyllou
Feb 10, 2016·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Rei TohyamaAkira Yamaguchi
Sep 1, 2005·Oral Oncology·Julia Anne Woolgar, Asterios Triantafyllou
Sep 13, 2005·International Journal of Oral and Maxillofacial Surgery·R Shaw
Aug 20, 2005·Oral Oncology·Eric M GendenAlfio Ferlito
May 30, 2015·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Chunjie LiLongjiang Li
Feb 15, 2015·Biochemical and Biophysical Research Communications·Ryosuke NakamuraAkira Yamaguchi
Jan 14, 2016·The Lancet Oncology·James S BrownRichard Shaw
Sep 14, 2016·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Chunjie LiLongjiang Li
Jul 21, 2016·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Olivier CamuzardAlexandre Bozec
Sep 8, 2015·Cancers·Shellese A Cannonier, Julie A Sterling
Jan 2, 2019·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Jumah G AhmadLester J Layfield

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