The influence of the renin angiotensin system on abnormal expression of nerve growth factor in the spontaneously hypertensive rat

Clinical and Experimental Pharmacology & Physiology
S JeffresonR J Head

Abstract

1. The levels of the neurotrophic factor, nerve growth factor (NGF) in the mesenteric vascular bed of the spontaneously hypertensive rat (SHR) were greater than those in the corresponding vascular bed of normotensive Wistar-Kyoto rats (WKY). 2. Administration of angiotensin II (200 ng/kg per min, by minipump) for 2 weeks to juvenile WKY rats increased the levels of NGF in the mesenteric vasculature to those seen in untreated SHR. 3. Administration of the angiotensin II receptor antagonists losartan (30 mg/kg per day, p.o.) or PD144277 (10 mg/kg per day, p.o.) to juvenile SHR for 4 weeks reduced the levels of NGF such that they were indistinguishable from the values obtained for normotensive WKY rats. 4. The results confirm the elevated level of NGF in the mesenteric vasculature of the SHR and suggest that angiotensin II may play a role in regulating the abnormal concentrations of the protein in this tissue.

References

Aug 1, 1992·Clinical and Experimental Pharmacology & Physiology·P H FalckhR J Head
Jan 11, 1991·Brain Research·C ZettlerR A Rush
Dec 1, 1991·Hypertension·D Creedon, J B Tuttle

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Citations

Aug 1, 1997·Clinical and Experimental Pharmacology & Physiology·R A RushX F Zhou
Apr 6, 2000·American Journal of Physiology. Heart and Circulatory Physiology·F A le NobleC E Blanco
Sep 8, 2017·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Wenfeng ShangguanXuewen Wang
Oct 3, 1999·Physiological Reviews·J Zicha, J Kunes
Nov 29, 2001·Journal of Hypertension·S H Zhang, R A Rush
Sep 23, 2020·British Journal of Clinical Pharmacology·Jennifer H Martin, Richard Head

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