PMID: 9528684Apr 7, 1998Paper

The influence of the route of administration and liposome composition on the potential of liposomes to protect tissue against local toxicity of two antitumor drugs

Biochimica Et Biophysica Acta
C OussorenJ Zuidema

Abstract

The present paper reports on the influence of the route of administration and liposome stability on the protective effect of liposome encapsulation of two model antitumor agents, mitoxantrone and doxorubicin. The results demonstrate that liposome encapsulation can protect surrounding tissue from the cytotoxic effects of the drugs after subcutaneous (s.c.) and intramuscular (i.m.) administration. The route of administration is an important factor influencing tissue damage. Liposomal mitoxantrone caused much less tissue irritation after im injection than after s.c. injection. Liposome stability is also an important factor. Liposomes composed of 'fluid-state' phospholipids only delayed the damaging effects of doxorubicin when injected sc. Liposomes with a more rigid nature were much more effective in preventing local tissue damage over a longer period of time when administered sc. Results suggest that slow release of liposome-associated drugs may eventually cause severe local tissue damage. The incorporation of the hydrophilic lipid derivative distearoylphosphatidylethanolamine-poly(ethyleneglycol) (PEG-PE) had no apparent effect on the protective effect of liposomes after sc administration.

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Citations

Mar 12, 2010·Pharmaceutical Research·Bing GuWeiyue Lu
Aug 8, 2001·Advanced Drug Delivery Reviews·C Oussoren, G Storm
Feb 14, 2006·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Bin LuRuo-Bing Chao
Feb 9, 2010·Journal of Drug Targeting·Linglin FengWeiyue Lu
Nov 8, 2005·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Aristarchos PapagiannarosCostas Demetzos
Nov 18, 1998·Journal of Microencapsulation
Jul 28, 2020·Nanomaterials·Chunhua Yang, Didier Merlin
May 26, 2021·Nanoscale Research Letters·Foad Rommasi, Neda Esfandiari

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