PMID: 19928660Nov 26, 2009Paper

The influence of the total immunoglobulin E level concentration in serum on the results of atopy patch tests in adult patients with atopic dermatitis

Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
Witold Owczarek, Elwira Paluchowska

Abstract

Atopy patch tests (APT) are defined as epidermal tests with allergens typically generating IgE related reactions with the assessment of consecutive eczematous conditions. They are showing allergen specific IgE on Langerhans cells surface. Increased total IgE concentration in serum is observed in 40-75% of atopic dermatitis (AD) patients, and these class antibodies titer is one of the small criterions in AD condition diagnosis (according to Hanifin & Rajka). To assess the correlation of APT results with the total class E antibodies serum levels. 115 AD patients were examined. APT were done using a single allergen extract or their mix from commercially available reagents from Stallergenes (France). The determination of antigen specific IgE was done with fluoroimmunoenzymatic assay using Pharmacia CAP System FEIA set from Pharmacia-LKB (Sweden). In 50% AD patients with positive APT results increased total IgE levels were found. The correlation between positive APT results and increased total IgE levels was not statistically significant. It has been proved that the number of positive APT results was correlated positively with total IgE levels, this tendency was also observed for all tested allergens Conducted studies on APT usefuln...Continue Reading

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Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

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