The influence of thyroid hormone replacement in a porcine brain death model

Transplantation
I SchwartzR Hickman

Abstract

This study was conducted to determine whether the administration of tri-iodothyronine (T3) to brain-dead donor pigs would improve hemodynamic instability, serum levels of thyroid hormones, or the outcome of transplantation of donor livers. Brain death was caused in young pigs (25-38 kg) by rapid inflation of an intracranially implanted balloon catheter. The animals were maintained on a ventilator and frequent measurements of acid/base balance, electrolytes, and glucose were made. At the end of 16 hr, livers were removed and implanted into prepared recipients. Serum-free tri-iodothyronine fell to zero at the end of 16 hr, and there was a 4-6-fold decline in free thyroxine (T4). The levels of serum reverse T3 (rT3) however, increased up to 6-fold. In animals treated with tri-iodothyronine 2 micrograms/hr, the serum levels of free T3 and T4 were not changed but the levels of serum reverse T3 (rT3) increased further. There were no apparent correlations between any hemodynamic parameter and serum thyroid hormone levels in the donors. After the liver transplants, recipients could be divided into those that survived longer than 6 days and those that did not. Although there were significant differences in the plasma levels of alanine a...Continue Reading

Citations

Jun 1, 1995·Journal of Critical Care·H B BittnerP Van Trigt
Aug 10, 2000·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·P ChiariR Ferrera
Aug 1, 1996·Critical Care Medicine·E P ChenP Van Trigt
Nov 1, 1995·British Journal of Haematology·A G Dalgleish
May 1, 2007·Frontiers of Medicine in China·Shuijun ZhangShi Chen
Jul 1, 1996·The Annals of Thoracic Surgery·T V VotapkaM T Swartz
May 16, 2015·Critical Care Medicine·Robert M KotloffUNKNOWN Society of Critical Care Medicine/American College of Chest Physicians/Association of Organ Procurement Organizations Donor
Mar 10, 2020·Transplantation·Louise E See HoeJohn F Fraser

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