The Influence of Thyroid Pathology on Osteoporosis and Fracture Risk: A Review

Diagnostics
Dragos ApostuHorea Benea

Abstract

Thyroid hormones are important factors that regulate metabolism and cell differentiation throughout the human body. A complication of thyroid pathology is represented by an alteration of the bone metabolism which can lead to osteoporosis and fragility fractures, known to have a high mortality rate. Although there is a consensus on the negative impact of hyperthyroidism on bone metabolism, when referring to hypothyroidism, subclinical hypothyroidism, or subclinical hyperthyroidism, there is no general agreement. The aim of our review was to update clinicians and researchers about the current data regarding the bone health in hypothyroidism, subclinical hypothyroidism, and subclinical hyperthyroidism patients. Thyroid disorders have an important impact on bone metabolism and fracture risk, such that hyperthyroidism, hypothyroidism, and subclinical hyperthyroidism are associated with a decreased bone mineral density (BMD) and increased risk of fracture. Subclinical hypothyroidism, on the other hand, is not associated with osteoporosis or fragility fractures, and subclinical hyperthyroidism treatment with radioiodine could improve bone health.

References

Jul 5, 2002·Thyroid : Official Journal of the American Thyroid Association·Peter Vestergaard, Leif Mosekilde
Jan 17, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Christian MeierMarius Kraenzlin
Apr 21, 2006·Archives of Medical Research·Won Young LeeSung Woo Park
Aug 13, 2009·European Journal of Endocrinology·Anders SvareArnulf Langhammer
Mar 3, 2010·The Journal of Bone and Joint Surgery. American Volume·Aasis UnnanuntanaJoseph M Lane
Nov 26, 2010·Archives of Internal Medicine·Jennifer S LeeJohn Robbins
Jul 28, 2012·Indian Journal of Endocrinology and Metabolism·Raman K MarwahaKuntal Bhadra
Aug 7, 2013·Orphanet Journal of Rare Diseases·Doina PiciuRares Buiga
Jul 1, 2012·Hormones : International Journal of Endocrinology and Metabolism·Snezana PolovinaDragan Micic
Feb 27, 2014·Journal of Preventive Medicine and Public Health = Yebang Ŭihakhoe Chi·Young-Jin KoByung-Joo Park
Mar 1, 2013·European Thyroid Journal·Graham R Williams
Jun 1, 2014·The Journal of Clinical Endocrinology and Metabolism·Margaret C GarinAnne R Cappola
Oct 21, 2014·Journal of Research in Pharmacy Practice·Mansoor KarimifarMozhgan Karimifar
Nov 29, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Bo AbrahamsenHegedüs Laszlo
Apr 11, 2015·Clinical Medicine Insights. Women's Health·Ruby P BabuVivian D'Souza
May 27, 2015·JAMA : the Journal of the American Medical Association·Manuel R BlumUNKNOWN Thyroid Studies Collaboration
Aug 1, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Z YanJ Wang
Feb 11, 2016·Endocrine Reviews·J H Duncan Bassett, Graham R Williams
Mar 30, 2016·Journal of Bone and Mineral Metabolism·Irene LambrinoudakiXenofon Papacharalambous
Apr 8, 2016·Physiology·Jawed A Siddiqui, Nicola C Partridge
Apr 8, 2016·Expert Opinion on Pharmacotherapy·Luigi GennariDaniela Merlotti
Jun 23, 2016·Calcified Tissue International·Ceyla Konca DegertekinMetin Arslan
Nov 4, 2016·BioMed Research International·Giuseppe MaccagnanoBiagio Moretti
Mar 16, 2017·European Journal of Rheumatology·Tümay SözenNursel Çalık Başaran
Mar 25, 2017·Lancet·Layal ChakerRobin P Peeters
Apr 14, 2017·Post Reproductive Health·Christopher Redford, Bijay Vaidya
Oct 17, 2017·Journal of Internal Medicine·D SegnaUNKNOWN Thyroid Studies Collaboration
Oct 19, 2017·Frontiers in Endocrinology·Ramkumarie BaliramTerry F Davies
Sep 16, 2018·Hormone Molecular Biology and Clinical Investigation·Konstantinos TsevisPeriklis Panagopoulos
Mar 29, 2019·World Journal of Orthopedics·Colum DowneyJohn F Quinlan
May 6, 2019·Drug Metabolism Reviews·Alexandru MesterSimion Bran
Nov 7, 2019·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·Etienne RapackiDebbie Norring-Agerskov
Nov 9, 2019·The Journal of Clinical Endocrinology and Metabolism·Elena Gonzalez RodriguezNicolas Rodondi
Nov 14, 2019·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·K LeeM J Kwon

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Citations

Jul 31, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Alexander Kalinkovich, Gregory Livshits

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Methods Mentioned

BETA
X-ray

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