Abstract
Triclosan toothpaste is effective in controlling plaque and gingivitis and slowing progression of periodontitis; however, its influence on inflammatory biomarkers of cardiovascular disease (CVD), as well as on kidney and liver function, is unknown. Patients recruited from the Cardiovascular Unit at Prince Charles Hospital, Brisbane, Australia, were randomized to triclosan (n = 193) or placebo (n = 190) groups and assessed for total cholesterol (TC), high density lipoprotein (HDL) and low density lipoprotein (LDL) cholesterol, triglycerides, C-reactive protein, erythrocyte sedimentation rate (ESR), hemoglobin, total white cell count (WCC), estimated glomerular filtration rate (eGFR), and liver function enzymes, annually for 5 years. A standard mixed model for each marker included group, sex, age, hypertension, diabetes, periodontal status, statin and anti-inflammatory drug use, and smoking as covariates. Changes in eGFR, WCC, and ESR were further analyzed using transition modeling. Triclosan toothpaste led to a greater decrease in TC (P = 0.03), LDL cholesterol (P = 0.04), and HDL cholesterol (P = 0.05) than placebo toothpaste. ESR increased at a slower rate in the triclosan group (P ≈ 0.06) and was less likely to increase and m...Continue Reading
References
Jan 1, 1975·Toxicology·J G BlackT Rutherford
Jan 27, 1998·Journal of Clinical Periodontology·B RoslingJ Lindhe
Jul 3, 1998·Journal of Clinical Periodontology·R P EllwoodR M Davies
Apr 25, 2000·Journal of Periodontology·M J FaddyG J Seymour
Sep 16, 2000·European Heart Journal·G ErikssenJ Erikssen
Apr 20, 2001·JAMA : the Journal of the American Medical Association·D MoherUNKNOWN CONSORT Group (Consolidated Standards of Reporting Trials)
Nov 1, 2001·Journal of Clinical Periodontology·J W HutterB G Loos
May 25, 2002·Journal of Periodontology·Joseph KatzMarc Heft
Apr 29, 2003·Journal of Clinical Periodontology·M P CullinanG J Seymour
May 24, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Salomon AmarJoseph A Vita
Jun 11, 2003·Journal of Clinical Periodontology·M P CullinanG J Seymour
Oct 31, 2003·American Journal of Epidemiology·Margret B AndresdottirVilmundur Gudnason
Jan 8, 2004·Atherosclerosis·Michael HoffmanMoshe Benjamin
Jan 27, 2004·Journal of Dental Research·K J JoshipuraE B Rimm
Dec 22, 2004·Circulation·Thomas A PearsonUNKNOWN AHA
Dec 24, 2004·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Pirkko J PussinenPekka Jousilahti
Feb 5, 2005·Journal of Clinical Periodontology·L MontebugnoliG Melandri
Mar 1, 2005·Journal of Periodontology·Fehmi MercanogluSabahattin Umman
Apr 5, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Abhijit V KshirsagarRonald J Falk
Apr 29, 2006·American Heart Journal·Francesco D'AiutoMaurizio S Tonetti
Sep 30, 2006·The Science of the Total Environment·Mats AllmyrGunilla Sandborgh-Englund
Mar 3, 2007·The New England Journal of Medicine·Maurizio S TonettiJohn Deanfield
Jul 21, 2007·Southern Medical Journal·S Gul OzTumay Sozen
Nov 6, 2007·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·G J SeymourK Yamazaki
Oct 31, 2007·American Heart Journal·Amol Ashok BahekarRohit Arora
Jan 22, 2008·The Science of the Total Environment·Mats AllmyrGunilla Sandborgh-Englund
Mar 13, 2008·Environmental Health Perspectives·Antonia M CalafatLarry L Needham
May 3, 2008·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Jake OlivierGailen D Marshall
Aug 2, 2008·Innate Immunity·K A Elisa KallioPirkko J Pussinen
Sep 23, 2008·Journal of General Internal Medicine·Linda L HumphreyMark Helfand
Aug 8, 2009·British Dental Journal·Anthony BlinkhornG J Seymour
Oct 2, 2009·Journal of Periodontology·Syed Akhtar Hussain BokhariMateen Izhar
May 29, 2010·Journal of Clinical Periodontology·Silvana P BarrosSteven Offenbacher
Jun 16, 2010·Journal of Clinical Periodontology·Filippo GrazianiFrancesco D'Aiuto
Jul 29, 2010·European Journal of Oral Sciences·Barbara TaylorKarl Schenck
Aug 19, 2010·Clinical Oral Investigations·Naofumi TamakiManabu Morita
Aug 24, 2011·Journal of Periodontology·Lei ChenJincai Zhang
Dec 27, 2011·The Science of the Total Environment·Mary P CullinanGregory J Seymour
Apr 20, 2012·Circulation·Peter B LockhartUNKNOWN American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee of the Council on Cardiovascular Di
Feb 26, 2013·Journal of Clinical Periodontology·Leandro ChambroneGiuseppe A Romito
May 3, 2013·Journal of Clinical Periodontology·Francesco D'AiutoJohn C Gunsolley
Oct 2, 2013·Oral Diseases·M A WalletS M Wallet
Apr 17, 2014·Advances in Dental Research·Y W HanM Tezal
Jul 22, 2014·Journal of Clinical Periodontology·André Luis CaúlaRicardo Guimarães Fischer
Dec 3, 2014·The Science of the Total Environment·Mary P CullinanGregory J Seymour