PMID: 6628521Jan 1, 1983

The influence of uremia on the accessibility of phosphomycin into interstitial tissue fluid

European Journal of Clinical Pharmacology
C Fernandez LastraM Yuste Chaves

Abstract

The entry and persistence of phosphomycin in interstitial tissue fluid (ITF) were studied in 9 patients with normal renal function and 8 patients with varying degrees of renal impairment, all of whom received a single i.v. dose of 30 mg/kg. ITF was obtained from skin blisters produced by suction. The antibiotic followed a two-compartment open kinetic model. In patients with normal renal function, phosphomycin is incorporated rapidly into the ITF reaching a level of 60.4 micrograms/ml 60 min after administration. There was no statistically significant difference between the elimination rates from serum and ITF. The serum half-life of the slow disposition phase was 1.75 h in patients with normal renal function. There was a linear correlation between the elimination half-life of phosphomycin in serum and ITF in subjects with differing degrees of renal impairment.

References

Apr 1, 1984·Antimicrobial Agents and Chemotherapy·C F LastraA D Gil
Sep 19, 2000·Antimicrobial Agents and Chemotherapy·M FrossardM Müller
Jul 12, 2011·Clinical Pharmacokinetics·Friederike TraunmüllerChristian Joukhadar
Apr 1, 1984·British Journal of Clinical Pharmacology·C Fernandez LastraJ Grande Villoria
Nov 1, 2017·Antibiotics·Anneke C DijkmansIngrid M C Kamerling
Jul 28, 2020·The Journal of Antimicrobial Chemotherapy·Sander G KuiperCees van Nieuwkoop

Citations

Jan 1, 1977·Clinical Pharmacokinetics·E Iisalo
Jul 1, 1977·Clinical Pharmacokinetics·L F Gram
Jan 1, 1978·Drug Metabolism Reviews·M M Reidenberg, D E Drayer
Sep 1, 1979·European Journal of Clinical Pharmacology·M J GarciaJ A Sanchez Tomero
Jan 1, 1977·Chemotherapy·R CadórnigaT Olay
Sep 1, 1976·Antimicrobial Agents and Chemotherapy·T MadhavanE L Quinn
Jan 1, 1976·Antimicrobial Agents and Chemotherapy·B R MeyersS Z Hirschman
May 1, 1971·Journal of Pharmaceutical Sciences·K C KwanE L Foltz
Apr 1, 1969·Journal of Pharmaceutical Sciences·G LevyW J Jusko

Related Concepts

Kidney Function Tests
Kidney Failure
Bulla
Fosfomycin
Extracellular Space
Renal Insufficiency
Uremia
Ichthyosis, Mental Retardation, Dwarfism, and Renal Impairment
Anatomical Compartments
Total Body Clearance Rate

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