The influence of vagal afferents on the left ventricular contractile response to intracoronary administration of catecholamines in the conscious dog

Circulation Research
K W Barron, V S Bishop

Abstract

We studied the effect of vagal afferents on the left ventricular contractile response (LVdP/dtmax) to administration of sympathomimetic amines into the left circumflex coronary artery in conscious dogs. The positive inotropic effects of bolus administration of epinephrine, norepinephrine, and isoproterenol were greater during bilateral vagal cold block (BVB) that in the control state with the vagi intact (P less than 0.001). The inotropic potentiation observed with BVB was not due to vagal efferent interruption, since parasympathetic efferent block with atropine did not potentiate the inotropic effects of intracoronary epinephrine (P greater than 0.05). BVB also potentiated the inotropic effects of constant intracoronary infusion of epinephrine (P less than 0.01). BVB alone had no significant effect on LVdP/dtmax; dtmax (P less than 0.05). We propose that the potentiation of the inotropic effects during BVB could result from either interruption of a vagal afferent-mediated negative feedback reflex and/or an unmasking of a sympathetic afferent-mediated positive feedback effect induced by BVB. However, the observations that ganglionic blockade also potentiated the contractile effects of epinephrine supports the concept that a neg...Continue Reading

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Citations

Jan 1, 2013·World Journal of Pediatrics : WJP·Baris GuvenTimur Mese
Dec 1, 1988·Journal of the American College of Cardiology·M FromerM Shenasa
Nov 26, 2004·Clinical Cardiology·Wan Leong ChanChi Woon Kong
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Jan 1, 1989·The American Journal of Cardiology·M B WaxmanJ Roseman
Sep 16, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Kentaro YamakawaMarmar Vaseghi

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