PMID: 6105179Jul 1, 1980Paper

The influence of various counter ions on the interaction of chlorhexidine with the hydrophilic contact lens polymer, poly(2-hydroxyethyl methacrylate)

The Journal of Pharmacy and Pharmacology
B S PlautD J Davies

Abstract

The commercially available salts of chlorhexidine were found to interact with the hydrogel poly (2-hydroxyethyl methacrylate) to different extents, the affinity for the polymer decreasing in the order acetate, gluconate, chloride. The uptakes of the acetate and gluconate salts were almost entirely irreversible over the concentration range studied. The influence of some alternative counter ions, namely amino acids and dicarboxylic acid salts, was examined and found to generate a three-fold variation in the extent of the chlorhexidine interaction. Uptakes were greatest for counter ions that were either hydrophobic in character or bore a net negative charge. Only two compounds, glycine and monosodium oxalate, were successful in reducing the extent of sorption below that observed for chlorhexidine hydrochloride.

References

Dec 1, 1977·The Journal of Pharmacy and Pharmacology·N E RichardsonD A Norton
Aug 1, 1978·The Journal of Pharmacy and Pharmacology·N E RichardsonD A Norton
Nov 1, 1978·The Journal of Pharmacy and Pharmacology·D L Mackeen, K Green
Mar 1, 1974·The Journal of Pharmacy and Pharmacology·N E Richardson, B J Meakin
Jun 1, 1974·American Journal of Optometry and Physiological Optics·G L Cureton, N C Hall
Feb 1, 1972·The British Journal of Ophthalmology·J Dallos, W H Hughes
Jun 1, 1971·Journal of Chemical Education·G E Clement, T P Hartz
Jun 1, 1958·The Journal of Pharmacy and Pharmacology·A HOLBROOK
Oct 1, 1964·The Journal of Pharmacy and Pharmacology·W B HUGO, A R LONGWORTH

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Citations

Apr 16, 2003·Eye & Contact Lens·C C S KarlgardC Moresoli
Sep 1, 1992·Journal of Cataract and Refractive Surgery·J M ChapmanK Green
Jan 20, 2011·European Journal of Oral Sciences·Raquel OsorioManuel Toledano
Feb 1, 1981·The British Journal of Ophthalmology·J Morris, M Ruben
Aug 1, 1980·The Journal of Pharmacy and Pharmacology·B S PlautD J Davies
Feb 1, 1981·The Journal of Pharmacy and Pharmacology·B S PlautN E Richardson

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