The influence of vascular risk factors on cognitive function in early Parkinson's disease

International Journal of Geriatric Psychiatry
Maxime DoironMartine Simard

Abstract

Hypertension, dyslipidemia, diabetes, and obesity are well-established risk factors for cognitive impairment and dementia in older adults. In contrast, previous studies that have assessed the impact of vascular risk factors (VRFs) on cognition in Parkinson's disease (PD) have had methodological limitations and reported conflicting findings. We address this question in a large well-characterized cohort of de novo PD patients. A total of 367 untreated and non-demented patients aged 50 years and older with early PD (H&Y = 1.0-2.0) underwent a comprehensive clinical and neuropsychological assessment at baseline and 24 months later. A series of linear mixed models were used to determine the effects of VRFs on cognition while controlling for patient and disease characteristics. The outcomes included norm-referenced Z-scores of global cognition, visuospatial skills, verbal episodic memory, semantic verbal fluency, attention, and working memory tests. A longer history of hypertension and a higher pulse pressure were significant predictors of lower Z-scores on immediate and delayed free recall, recognition, and verbal fluency tests. On average, every 10 mmHg increase in pulse pressure was associated with a 0.08 reduction on the cognitiv...Continue Reading

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Citations

Sep 1, 2018·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·L M ChahineC T McMillan
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Dec 16, 2021·Clinics·Ana Patrícia da Silva SouzaViviane de Oliveira Nogueira Souza

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