Jul 16, 1976

The influence of vitamin a, gentamicin and anoxaemia on urinary enzyme excretion (author's transl)

Wiener klinische Wochenschrift
R KolbF Zekert

Abstract

The excretion patterns of several urinary enzymes were investigated in the following four experimental groups of Wistar rats and compared with the normal range of each urinary enzyme studied. One group received vitamin A in high dosage; a second group was given vitamin A before and after bilateral clamping of the renal artery for 30 minutes; in the third group the renal arteries were clamped for 30 or 60 minutes; the last group of experimental animals received first low (2mg/kg, 4mg/kg) and subsequently high doses (100 mg/kg) of gentamicin. Vitamin A administration produced no increase in urinary enzyme activity, even in the group of rats with ischaemically-damaged kidneys, where ischaemia (clampin of the arteries) was responsible per se for an increase in enzyme excretion. With low doses of gentamicin the urinary enzymes remained within normal limits, but increased immediately to significantly pathological values after the first dose 100 mg/kg gentamicin.

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Mentioned in this Paper

Ischemia
Vitamin A
Arterial System
Enzymes, antithrombotic
Gentamicins
Malate Dehydrogenase
Gentacycol
Gamma-glutamyl transferase
Methoxyleucine Aminopeptidase
Kidney

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