The influence of vitamin D receptor genetic variants on bone mineral density and osteoporosis in Chinese postmenopausal women

Disease Markers
Wei HeWei Gao

Abstract

Growing evidence indicates that the vitamin D receptor (VDR) gene is an important candidate gene for influencing the development of osteoporosis. The aim of the study was to evaluate the potential association between genetic variants of VDR gene and bone mineral density (BMD) and osteoporosis in Chinese postmenopausal women. The study included 970 Chinese postmenopausal women at the postmenopausal osteoporosis (482) and healthy controls (488). The BMD of lumbar spine (L(2-4) anterior-posterior view), femoral neck hip, and total hip was evaluated using the Norland XR-46 dual energy X-ray absorptiometry (DEXA). The genotypes of VDR genetic variants were determined by the created restriction site-PCR (CRS-PCR) and confirmed by DNA sequencing methods. Our data indicated that the VDR p.Glicine (Gly)14 alanine (Ala) and p.histidine (His) 305 glutanine (Gln) genetic variants were statistically associated with adjusted femoral neck hip BMD, adjusted lumbar spine BMD, and adjusted total hip BMD (P values < 0.05). Results from this study suggest that the VDR p.Gly14Ala and p.His305Gln genetic variants are significantly associated with BMD decrease in Chinese postmenopausal women and might be used as molecular markers for assessing the ri...Continue Reading

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Citations

Oct 6, 2017·Journal of Nutritional Science and Vitaminology·Sajjad MoradiKhadijeh Mirzaei
May 14, 2019·Frontiers in Genetics·Abjal Pasha ShaikAsma Sultana Shaik

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Methods Mentioned

BETA
X-ray
PCR
electrophoresis
genotyping

Software Mentioned

SPSS
Statistical Package for Social Sciences software ( SPSS
Primer Premier

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