PMID: 8956342Nov 1, 1996Paper

The influence of water on electrostatic charge retention and dissipation in pharmaceutical compacts for powder coating

Pharmaceutical Research
M P Grosvenor, J N Staniforth

Abstract

The electrostatic properties of five materials commonly used in tabletting were investigated to assess their suitability for the novel technique of powder coating of pharmaceutical compacts. Powder resistivity and compact voltage decay properties were determined under dry and wet conditions using purpose built equipment. The organic materials acted as insulators having resistivities > 10(13) omega m whilst dibasic calcium phosphate showed dielectric behaviour. A clear relationship between water content and resistivity was established for all materials. Electrical conduction across powder surfaces was demonstrated as the predominant mechanism by using low concentrations of magnesium stearate. In materials absorbing significant water a bulk mechanism was also present. After charge injection, decay rates were dependent on resistivity with those having the highest values exhibiting the slowest decay. The chemical nature of the materials was unimportant except at extremely high resistivities. Conditioning of the compacts with water reduced resistivities so that decay half-lives < 1 s were achieved. The electrical properties of the compact materials have been modified sufficiently to enable them to be considered suitable for powder c...Continue Reading

Citations

Jul 15, 2017·Drug Development and Industrial Pharmacy·Anastasia Anna FoppoliAndrea Gazzaniga
Jul 11, 2007·Pharmaceutical Research·Philip Chi Lip Kwok, Hak-Kim Chan
Jun 27, 2008·Pharmaceutical Research·Keat Theng ChowPaul W S Heng
Nov 6, 2020·International Journal of Pharmaceutics·M BerettaA Paudel
Nov 5, 2016·International Journal of Pharmaceutics·Leena Kumari PrasadJames W McGinity

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