The influenza virus nucleoprotein: a multifunctional RNA-binding protein pivotal to virus replication

The Journal of General Virology
Agustín Portela, Paul Digard

Abstract

All viruses with negative-sense RNA genomes encode a single-strand RNA-binding nucleoprotein (NP). The primary function of NP is to encapsidate the virus genome for the purposes of RNA transcription, replication and packaging. The purpose of this review is to illustrate using the influenza virus NP as a well-studied example that the molecule is much more than a structural RNA-binding protein, but also functions as a key adapter molecule between virus and host cell processes. It does so through the ability to interact with a wide variety of viral and cellular macromolecules, including RNA, itself, two subunits of the viral RNA-dependent RNA polymerase and the viral matrix protein. NP also interacts with cellular polypeptides, including actin, components of the nuclear import and export apparatus and a nuclear RNA helicase. The evidence for the existence of each of these activities and their possible roles in transcription, replication and intracellular trafficking of the virus genome is considered.

References

Aug 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·M L Privalsky, E E Penhoet
Dec 1, 1977·Virology·A J HayJ J Skehel
Sep 1, 1990·The Journal of General Virology·M KurokawaS Niwayama
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M T HsuP Palese
Nov 11, 1989·Nucleic Acids Research·L Wakefield, G G Brownlee
Sep 1, 1989·The Journal of General Virology·O KistnerC Scholtissek
Dec 1, 1988·Journal of Biochemistry·A HondaA Ishihama
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·A R Beaton, R M Krug
Oct 1, 1972·Journal of Virology·R W CompansP H Duesberg
Mar 31, 1971·Nature: New Biology·R J Young, J Content
Jan 1, 1971·The Journal of General Virology·C Scholtissek, H Becht
Jun 28, 1969·Journal of Molecular Biology·P H Duesberg
Sep 1, 1983·Journal of Virology·D R LondoD P Nayak
Mar 1, 1984·The Journal of General Virology·S G Markushin, Y Z Ghendon
Jan 30, 1982·Virology·A J HayJ McCauley
Apr 1, 1981·Journal of Virology·J S RobertsonR A Lazzarini
Mar 1, 1981·The Journal of General Virology·P J Rees, N J Dimmock
Aug 1, 1995·Trends in Biochemical Sciences·A Sugino
Mar 14, 1995·Proceedings of the National Academy of Sciences of the United States of America·J MoroianuA Radu

❮ Previous
Next ❯

Citations

Mar 19, 2013·FEBS Letters·Wenjie Zheng, Yizhi Jane Tao
Nov 4, 2015·International Journal of Molecular Sciences·Zhe ZhangQiqing Zhang
Feb 5, 2013·Expert Opinion on Drug Discovery·Woo-Jin Shin, Baik Lin Seong
Dec 22, 2015·European Journal of Medicinal Chemistry·Siwen NiuWenhan Lin
Jun 19, 2012·Drug Discovery Today·Juan DuHuan-Xiang Zhou
Jan 11, 2016·Wiley Interdisciplinary Reviews. RNA·Binbin DingMingzhou Chen
Dec 28, 2010·Journal of Virological Methods·Eiryo KawakamiYoshihiro Kawaoka
May 28, 2009·Science in China. Series C, Life Sciences·Andy Ka-Leung NgPang-Chui Shaw
May 12, 2009·Trends in Pharmacological Sciences·Robert M Krug, James M Aramini
May 12, 2009·Journal of Virological Methods·Hao-Tai ChenYong-Sheng Liu
Oct 18, 2008·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·L JossetM Rosa-Calatrava
Oct 2, 2007·Microbes and Infection·Fumitaka MomoseYuko Morikawa
Apr 3, 2008·Reviews in Medical Virology·Kyosuke NagataTadasuke Naito
Sep 20, 2011·Journal of Cellular Physiology·Ciro EspositoGiulio Tarro
Jun 27, 2013·Medicinal Research Reviews·Evelien Vanderlinden, Lieve Naesens
Mar 15, 2005·Virus Research·Vladimir Y LugovtsevRoland A Levandowski
Nov 30, 2004·Virus Research·Debi P NayakSubrata Barman
Dec 6, 2002·The Journal of General Virology·Eric Ka-Wai Hui, Debi P Nayak
Mar 20, 2009·The Journal of General Virology·Natalia L VarichNikolai V Kaverin
Apr 8, 2011·The Journal of General Virology·Ágnes FoegleinPaul Digard
Mar 7, 2009·The Journal of General Virology·Nicole C RobbErvin Fodor
Mar 7, 2009·The Journal of General Virology·Shohreh MahmoudianManfred Marschall
Dec 4, 2009·The Journal of General Virology·Edward C HutchinsonPaul Digard
Nov 19, 2015·Acta Pharmaceutica Sinica. B·Zuyuan ShenWei Wang
Feb 14, 2015·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Benjamin Schwarz, Trevor Douglas
Dec 7, 2013·Biochemical and Biophysical Research Communications·Peera Jaru-ampornpanAnan Jongkaewwattana
Jun 28, 2014·Biochemical and Biophysical Research Communications·Noriyuki HirataMasayuki Noguchi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.