The influx of ascorbic acid into the rat's brain

Quarterly Journal of Experimental Physiology : an International Journal of the Physiological Society
D K Lam, P M Daniel

Abstract

The influx of [14C]ascorbic acid into the rat's brain through the cerebral capillaries was measured by the steady-state initial-rate technique. Ascorbic acid was found to pass through the capillaries by a carrier-mediated process and by simple diffusion. The carrier system was found to have an apparent Vmax of 1.2 nmol . min-1 . g-1 of cerebral tissue and a Kt of 125 microM. The apparent constant of transfer, Kd, of the diffusional component was 0.98 microliter. min-1 . g-1. The contribution of the cerebral capillaries to the movement of ascorbic acid into the brain is discussed and was found to be the major route of entry into the brain for this vitamin.

Citations

Apr 27, 2000·Trends in Neurosciences·M E Rice
Oct 19, 2006·Pharmaceutical Research·Reynold Spector, Conrad Johanson
Dec 2, 2005·The International Journal of Neuroscience·Y Ziya ZiylanJean-Marie Bourre
Dec 4, 2015·International Journal of Molecular Sciences·Adriana Covarrubias-PintoMaite Aintzane Castro
Oct 18, 2016·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·M EsrefogluB Ates
Aug 1, 1994·Journal of Bioenergetics and Biomembranes·H Goldenberg, E Schweinzer
May 22, 2009·Journal of Neurochemistry·Maite A CastroIlona I Concha
Jul 2, 2003·Neurotoxicity Research·M E Rice
Dec 30, 2020·Antioxidants·Faraz Ahmad, Ping Liu
Jan 24, 2009·Free Radical Biology & Medicine·Fiona E Harrison, James M May

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