The infrapatellar fat pad is affected by injury induced inflammation in the rabbit knee: use of dexamethasone to mitigate damage

Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]
Bryan J HeardDavid A Hart

Abstract

The health of the infrapatellar fat pad (IFP) has been linked to pain, joint inflammation, and the onset of post-traumatic osteoarthritis. Thus, early inflammation effects on the IFP could have long term sequelae on joint integrity. This study was designed to characterize the natural history of the IFP in a model of surgically induced knee injury and inflammation, and to test the efficacy of one intra-articular (IA) administration of dexamethasone (DEX) immediately following surgery. An IA bone drill hole injury to the rabbit knee was conducted and immediately treated with DEX (n = 12). Early and late post-surgical time-points were investigated (48 h and 9 weeks) and the outcome measures were analysis of IFP histology, mRNA levels for relevant molecules, and protein levels for a subset of cytokines. Data were analyzed against a surgical control (injury without treatment; n = 12), a surgical sham (capsular incision only; n = 12), and normal control (n = 6). Single IA injection of DEX (0.5 mg/kg), administered at the completion of surgery. IFPs from injured joints exhibited significantly increased cellularity and early fibrosis at 48 h post surgery. While the histological inflammation from a capsular incision alone resolved, knee...Continue Reading

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Citations

Jun 4, 2016·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Kristen I BartonNigel G Shrive
Feb 15, 2018·Rheumatology·Hema Urban, Christopher B Little
May 17, 2019·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Bryan J HeardDavid A Hart
Apr 15, 2020·Journal of Extracellular Vesicles·Chang Hee WooYong Woo Cho
Oct 19, 2016·Current Opinion in Rheumatology·Carla R Scanzello
May 3, 2019·BioMed Research International·Elisa BelluzziVeronica Macchi

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