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The inherent mutational tolerance and antigenic evolvability of influenza hemagglutinin

bioRxiv

May 12, 2014

Bargavi Thyagarajan, Jesse D Bloom

Abstract

Influenza is notable for its evolutionary capacity to escape immunity targeting the viral hemagglutinin. We used deep mutational scanning to examine the extent to which a high inherent mutational tolerance contributes to this antigenic evolvability. We created mutant viruses that incorp...read more

Mentioned in this Paper

Site
Influenza
Influenza virus vaccine
Influenza A Virus, H1N1 Subtype
Mutation Abnormality
Passage Tissue Culture Technique
Influenza A virus
Antigens
Tissue Culture
Virus
3
1
Paper Details
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The inherent mutational tolerance and antigenic evolvability of influenza hemagglutinin

bioRxiv

May 12, 2014

Bargavi Thyagarajan, Jesse D Bloom

PMID: 990005041

DOI: 10.1101/005041

Abstract

Influenza is notable for its evolutionary capacity to escape immunity targeting the viral hemagglutinin. We used deep mutational scanning to examine the extent to which a high inherent mutational tolerance contributes to this antigenic evolvability. We created mutant viruses that incorp...read more

Mentioned in this Paper

Site
Influenza
Influenza virus vaccine
Influenza A Virus, H1N1 Subtype
Mutation Abnormality
Passage Tissue Culture Technique
Influenza A virus
Antigens
Tissue Culture
Virus
3
1
Paper Details
References
  • References
  • Citations
  • finger pointing at paper

    References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations
  • quote and clock

    No citations available

    This paper may not have been cited yet.
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