PMID: 18406747Aug 1, 1996Paper

The inhibin/activin family and ovarian cancer

Trends in Endocrinology and Metabolism : TEM
H G Burger, P J Fuller

Abstract

Ovarian cancer is the most common fatal malignancy of the female reproductive tract and frequently presents at an advanced stage. There is, thus, a great need for more sensitive and accurate methods of diagnosis, including better tumor markers. A rapidly emerging technique is the application of assays for the inhibin peptide family in patients with various forms of ovarian cancer. Currently, in assays that detect molecules containing the inhibin a subunit, more than 80% of postmenopausal patients with mucinous epithelial ovarian tumors, and virtually all with granulosa-cell tumors, have elevated inhibin levels. The detection of activin in some tumor tissues suggests that this peptide may also prove to be of interest once satisfactory and specific assays for the circulating peptide are available. It is likely that significant progress will be made in this field within the next 5 years.

References

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Citations

Oct 24, 1998·Journal of Reproductive Immunology·H G BurgerJ K Findlay
Jan 28, 1999·Molecular and Cellular Endocrinology·N A RahmanI T Huhtaniemi
Jan 6, 1999·Reproductive Toxicology·A M MahmoudC E Depuydt
Aug 11, 2011·Molecular and Cellular Endocrinology·Andrew N Shelling
May 18, 1999·Gynecologic Oncology·P J FullerH G Burger
Jan 15, 2002·The Journal of Clinical Endocrinology and Metabolism·Catherine S ChoongHenry G Burger
Mar 1, 1997·The Journal of Clinical Endocrinology and Metabolism·D M RobertsonN Groome

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