PMID: 6980873May 1, 1982Paper

The inhibition of bacterial beta-lactamases by some monocyclic beta-lactams

The Journal of Antibiotics
N S IsaacsC Reading

Abstract

The inhibition characteristics of 25 monocyclic beta-lactams mainly with an amido function at C3 have been studied against the beta-lactamases produced by 4 bacterial types. Significant levels of inhibition were found for only a few of the compounds tested and primarily against Staphylococcus beta-lactamase. The most active inhibitor tested, 3-p-nitrophenylacetamido-4-phenylazetidin-2-one, was found to require a cis geometry, the trans isomer being almost inactive.

Citations

Jan 1, 1986·Journal of Enzyme Inhibition·C Reading, M Cole
Oct 1, 1983·Medicinal Research Reviews·S J Cartwright, S G Waley

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