The inhibition of bone morphogenetic protein 1 attenuates endometriosis lesions in vivo and in vitro.

Archives of Gynecology and Obstetrics
Xinyue HanWei Wang

Abstract

To investigate the potential role of Bone morphogenetic protein 1 (BMP1) in endometriosis lesions. Endometriosis model in mice was established. The expression of BMP1-3 expression in mice of endometriosis lesions was evaluated. The effect of the treatment with anti-BMP1 antibodies on the expression of MMP2, MMP9, TGF-β, IL-17, IL-1β, Col1a1 and Col1a2 levels in mice was evaluated. In endometriosis cell model, the expression of IL-17, IL-1β, MMP2 and MMP9 levels and MIF, YWHAZ, β-catenin and CAP39 mRNA levels was also detected. The expression of BMP1-3 expression was upregulated in mice of endometriosis lesions (p < 0.01). Treatment with anti-BMP1 antibodies dose-dependently reduced MMP2, MMP9, TGF-β, IL-17, IL-1β, Col1a1 and Col1a2 levels in mice (p < 0.01). Treatment with anti-BMP1 antibodies suppressed TGF-β/PI3K/Akt signaling pathway. In vitro cell, si-BMP1 suppressed TGF-β/PI3K/Akt signaling pathway. The data support the hypothesis that the inhibition of BMP1 is involved in the pathogenesis of endometriosis lesions.

References

Oct 4, 2006·The Journal of Cell Biology·Gaoxiang Ge, Daniel S Greenspan
Nov 6, 2012·Applied and Environmental Microbiology·Xiaoxia LuoMing Sun
Feb 24, 2016·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Yan ZhouQing Xue
Sep 1, 2017·American Journal of Reproductive Immunology : AJRI·Ruiying DiaoYong-Gang Duan
Apr 19, 2018·Photomedicine and Laser Surgery·Ali Abd El-Monsif Thabet, Mansour Abdullah Alshehri
Mar 31, 2019·Journal of the College of Physicians and Surgeons--Pakistan : JCPSP·Yu YangYuhong Zhuang
Jun 21, 2019·Dose-response : a Publication of International Hormesis Society·Aixiu ZhouYuchun Lv
Jun 21, 2019·The Journal of Clinical Endocrinology and Metabolism·Arisa TakeuchiYutaka Osuga
Aug 29, 2019·Canadian Journal of Physiology and Pharmacology·Yan LiuJie Jiang
Sep 24, 2019·American Journal of Physiology. Renal Physiology·Mi BaiAihua Zhang

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