PMID: 6112975Dec 1, 1980Paper

The inhibition of cerebral high affinity receptor sites by lead and mercury compounds

Archives of Toxicology
S C Bondy, A K Agrawal

Abstract

The effect of various concentrations of several lead and mercury compounds upon various high affinity receptor sites within discrete brain regions has been measured. The specific binding of radioactive spiroperidol and quinuclidinyl benzilate to striatal and cortical membranes respectively, was much more severely inhibited in the presence of tri-n-butyl lead acetate than by lead acetate. This suggested that the hydrophobic organic lead derivative was able to interfere with receptor structure more readily than the lead acetate. On the other hand mercuric chloride was more effective in blocking these two neurotransmitter receptor sites than was the organic methylmercuric chloride. This implied that sulfhydryl groups may be within, or proximal to the allosteric binding site. The relative ineffectiveness of all heavy metal compounds studied in blocking the glycine. GABA or the diazepam receptors indicated that the mechanism of binding may not be similar with different receptor proteins. Since micromolar concentrations of some lead and mercury compounds suffice to severely inhibit neurotransmitter binding sites, such a direct interference with postsynaptic events may in part account for the neurological consequences of heavy metal p...Continue Reading

References

May 1, 1979·Toxicology and Applied Pharmacology·R S Aronstam, M E Elderfrawi
Aug 1, 1979·European Journal of Pharmacology·J S AguilarE De Robertis
Apr 1, 1975·Archives of Environmental Health·H RustamS El Hassani
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Mar 30, 1981·Toxicology and Applied Pharmacology·A K AgrawalS C Bondy
Jul 1, 1968·Journal of Biomechanics·A K Ommaya

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Citations

Dec 1, 1991·Neurochemical Research·K F Swaiman, V L Machen
Nov 1, 1985·Bulletin of Environmental Contamination and Toxicology·R N Ram, A G Sathyanesan
Sep 1, 1989·Bulletin of Environmental Contamination and Toxicology·R Agrawal, J P Chansouria
Dec 1, 1994·Cellular and Molecular Neurobiology·T NarahashiM Nakahiro
Jul 2, 2003·Neurotoxicity Research·Coral SanfeliuEduard Rodríguez-Farré
Aug 15, 1985·European Journal of Pharmacology·H KomulainenL Tuomisto
Jan 1, 1985·Progress in Neurobiology·G Audesirk
Jan 1, 1987·Toxicology in Vitro : an International Journal Published in Association with BIBRA·K SaijohK Sumino
Feb 1, 1997·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·B RajannaP R Yallapragada
Jun 1, 1991·Pharmacology & Toxicology·A RossiP Nicotera
Sep 10, 2014·International Journal of Environmental Research and Public Health·Francisco B TeixeiraRafael R Lima
May 11, 1992·Annals of the New York Academy of Sciences·P Nicotera, S Orrenius

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