PMID: 6405733Jan 1, 1983Paper

The inhibition of class C beta-lactamases by boronic acids

The Biochemical Journal
T BeesleyT Grundström

Abstract

Aromatic boronic acids are reversible inhibitors of the recently classified class C beta-lactamases. The boronic acids studied include ortho-, meta- and para-methyl-, -hydroxymethyl- and -formyl-phenylboronic acid. The beta-lactamases were chromosomally-encoded enzymes, one from Pseudomonas aeruginosa, and the other specified by the ampC gene of Escherichia coli. The inhibition may be correlated with our finding that these beta-lactamases are serine enzymes, i.e. their function entails the hydroxy group of a serine residue acting as a nucleophile.

Citations

Apr 1, 1992·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·I EliassonS G Waley
Sep 11, 2001·American Journal of Therapeutics·M P Groziak
Jan 13, 2010·Clinical Microbiology Reviews·Sarah M Drawz, Robert A Bonomo
Jan 1, 2014·Antimicrobial Agents and Chemotherapy·Sarah M DrawzRobert A Bonomo
Mar 20, 2014·PloS One·E Ascelijn ReulandNashwan al Naiemi
Jul 15, 2015·Expert Review of Anti-infective Therapy·Charbel Al-BayssariJean-Marc Rolain
Dec 21, 2016·Protein Science : a Publication of the Protein Society·Josephine P WernerRachel A Powers
Mar 20, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zeinab BreijyehRafik Karaman
Aug 1, 1996·Nature Structural Biology·N C StrynadkaJ B Jones
Jan 13, 2009·Clinical Microbiology Reviews·George A Jacoby
Nov 20, 1993·Biotechnology and Bioengineering·B D KelleyT A Hatton
Apr 10, 2010·The Journal of Antimicrobial Chemotherapy·Elizabeth B Hirsch, Vincent H Tam
Jan 20, 2012·Journal of Clinical Microbiology·André BirgyEdouard Bingen
Jun 3, 2011·Journal of Clinical Microbiology·Silke PolsfussMichael Hombach
Oct 28, 2016·Journal of Computer-aided Molecular Design·Jacopo SgrignaniGiovanni Grazioso
Jun 5, 2019·Experimental Biology and Medicine·Ben A Shurina, Richard C Page
Nov 13, 2019·Antimicrobial Agents and Chemotherapy·Ruslan Tsivkovski, Olga Lomovskaya
Dec 14, 1999·Protein Science : a Publication of the Protein Society·R A PowersB K Shoichet
Aug 11, 2015·Journal of Chemotherapy·Abed Zahedi BialvaeiMehdi Yousefi
Feb 1, 2018·Journal of Computer-aided Molecular Design·Stefania VillaGiovanni Grazioso
Oct 1, 1983·Medicinal Research Reviews·S J Cartwright, S G Waley
Apr 18, 2020·European Journal of Medicinal Chemistry·Jessica Plescia, Nicolas Moitessier
Mar 20, 2013·Indian Journal of Medical Microbiology·N O YilmazA Uzel
Aug 11, 2001·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Malcolm G. P. Page
Jul 1, 1986·Antimicrobial Agents and Chemotherapy·K Bush, R B Sykes
Apr 24, 2009·Journal of Clinical Microbiology·Fernando PasteranAlejandra Corso

❮ Previous
Next ❯

Related Concepts

Related Feeds

Beta-lactamase Inhibitors

Beta-lactamase inhibitors are a class of antibiotics that inhibit beta-lactamases, a family of enzymes involved in bacterial resistance to beta-lactam antibiotics. Here is the latest research.

Beta-lactamase Inhibitors (ASM)

Beta-lactamase inhibitors are a class of antibiotics that inhibit beta-lactamases, a family of enzymes involved in bacterial resistance to beta-lactam antibiotics. Here is the latest research.