The inhibition of DMBA-induced carcinogenesis by neoxanthin in hamster buccal pouch

Nutrition and Cancer
J M ChangJ K Lin

Abstract

Neoxanthin, a major carotenoid pigment of spinach, is found in the Chloroplast membrane and has an unknown function in plants. Neoxanthin inhibited the production of superoxide anions in an artificial xanthine and xanthine oxidase system and depressed DNA synthesis in methylcholanthrene (MCA)-initiated C3H10T1/2 fibroblasts. in two-stage carcinogenesis experiments, neoxanthin at 0.2 micrograms/0.2 ml inhibited the formation of tumors that were induced sequentially by 7,12-dimethylbenz[a]anthracene (DMBA) and 12-O-tetradecanoylphorbol-13-acetate (TPA) in the buccal pouch of Syrian Golden hamsters. To assess the ongoing process of carcinogenesis, the activity of ornithine decarboxylase (ODC), required for cell proliferation, was analyzed. Neoxanthin inhibited the activity of ODC when animals were treated with neoxanthin one hour before the application of TPA in two-stage carcinogenesis. However, neoxanthin did not inhibit ODC activity when animals were treated with neoxanthin one hour before the application of DMBA in two-stage carcinogenesis, and there was no subsequent tumor formation. In a short-term anti-initiation experiment, neoxanthin inhibited the covalent binding of isotope-labeled DMBA to DNA by 53%. These results indic...Continue Reading

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Citations

Jul 8, 2005·Applied Microbiology and Biotechnology·Prakash Bhosale, Paul S Bernstein
Mar 12, 2011·International Journal of Food Sciences and Nutrition·U G ChandrikaA K E Goonetilleke
Apr 14, 2011·BioFactors·Akihiko Nagao
Mar 2, 2005·Cancer Letters·Eiichi Kotake-NaraAkihiko Nagao
Sep 4, 2007·Progress in Lipid Research·Valery M Dembitsky, Takashi Maoka
Dec 12, 2001·The Journal of Nutrition·E Kotake-NaraA Nagao
Mar 23, 2021·Frontiers in Pharmacology·Umme Tamanna Ferdous, Zetty Norhana Balia Yusof
May 29, 2009·Journal of Agricultural and Food Chemistry·Nizar TliliSaida Triki
Jun 18, 2021·BioMed Research International·Azhar RasulXiaomeng Li

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