The inhibition of gamma-secretase as a therapeutic approach to Alzheimer's disease

Drug News & Perspectives
Taisuke Tomita, Takeshi Iwatsubo

Abstract

Alzheimer's disease is a dementing neurodegenerative disorder for which there is no effective treatment at present. Genetic and biological studies provide evidence that the production and deposition of amyloid-beta peptides (Abeta contribute to the etiology of Alzheimer's disease. gamma-Secretase is the pivotal enzyme in generating the C terminus of Abeta which determines its aggregability and speed of deposition. Drugs that regulate the production of Abeta by inhibiting gamma-secretase activity could provide an effective therapy for Alzheimer's disease, although recent studies suggest that gamma-secretase plays important roles in cellular signaling. This review focuses on studies of the gamma-secretase biology and provides the direction for developing effective and selective gamma-secretase inhibitors as drugs for the treatment of Alzheimer's disease.

Citations

Aug 26, 2006·Molecular Neurodegeneration·Taisuke TomitaTakeshi Iwatsubo
Feb 19, 2008·Genes & Development·Dina Arvanitis, Alice Davy
Jul 25, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Qi ShiRiqiang Yan
Nov 27, 2009·Neurochemical Research·Jane P HughesStephen D Skaper
Oct 24, 2012·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Alex ZhavoronkovAlexey Moskalev
Jan 1, 2006·Expert Opinion on Therapeutic Patents·Jean-Yves WinumClaudiu T Supuran
Mar 17, 2007·The Psychiatric Clinics of North America·Roy H Perlis
May 20, 2006·Medicinal Research Reviews·Jean-Yves WinumClaudiu T Supuran
Jan 5, 2005·Trends in Biotechnology·Susan A Greenfield
May 10, 2006·Bioorganic & Medicinal Chemistry Letters·Yasuko TakahashiTohru Fukuyama
Mar 21, 2006·Biochemical and Biophysical Research Communications·Toshihiko OguraChikara Sato
Sep 24, 2016·Journal of Alzheimer's Disease : JAD·Carolyn L FisherLinda K Nicholson
Apr 11, 2006·Harvard Review of Psychiatry·David S Jones, Roy H Perlis
Oct 20, 2005·The Journal of Biological Chemistry·Naoto WatanabeTakeshi Iwatsubo
Aug 13, 2009·The Journal of Pharmacology and Experimental Therapeutics·Robert L MartoneJ Steven Jacobsen
Dec 19, 2018·Proceedings of the National Academy of Sciences of the United States of America·Shenjie WuYigong Shi

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