The inhibition of IL-2/IL-2R gives rise to CD8+ T cell and lymphocyte decrease through JAK1-STAT5 in critical patients with COVID-19 pneumonia.

Cell Death & Disease
Hongbo ShiDexi Chen

Abstract

Although most patients with COVID-19 pneumonia have a good prognosis, some patients develop to severe or critical illness, and the mortality of critical cases is up to 61.5%. However, specific molecular information about immune response in critical patients with COVID-19 is poorly understood. A total of 54 patients were enrolled and divided into three groups, among which 34 were common, 14 were severe, and 6 were critical. The constitution of peripheral blood mononuclear cells (PBMC) in patients was analyzed by CyTOF. The profile of cytokines was examined in plasma of patients using luminex. The IL-2 signaling pathway was investigated in the PBMC of patients by qRT-PCR. The count and percentage of lymphocytes were significantly decreased in critical patients compared to common and severe patients with COVID-19 pneumonia. The count of T cells, B cells, and NK cells was remarkably decreased in critical patients compared to normal controls. The percentage of CD8+ T cells was significantly lower in critical patients than that in common and severe patients with COVID-19 pneumonia. The expression of IL-2R, JAK1, and STAT5 decreased in PBMC of common, severe, and critical patients, but IL-2 level was elevated in severe patients and de...Continue Reading

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Citations

Sep 11, 2020·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Georges Maestroni
Dec 11, 2020·International Immunopharmacology·Ritu Pasrija, Mohammad Naime
Feb 16, 2021·World Journal of Gastroenterology : WJG·Halina Cichoż-Lach, Agata Michalak
Jan 8, 2021·Frontiers in Immunology·Anthony J Leonardi, Rui B Proenca
Nov 23, 2020·Biochemical and Biophysical Research Communications·Bahire KalfaogluMasahiro Ono
Apr 1, 2021·European Journal of Immunology·Igor KosMoritz Bewarder
May 10, 2021·The Lancet. Respiratory Medicine·Marcin F OsuchowskiIgnacio Rubio
Jul 9, 2021·Signal Transduction and Targeted Therapy·Lan YangYufeng Zhou
Aug 7, 2021·Cell Death & Disease·David Della-MorteNicola Di Daniele
Oct 29, 2021·Journal of Medical Virology·Yuji YamamotoAtsushi Kumanogoh

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Methods Mentioned

BETA
X-ray
PCR

Software Mentioned

CyTOF

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