The inhibition of lamellar hydroxyapatite and lamellar magnetic hydroxyapatite on the migration and adhesion of breast cancer cells

Journal of Materials Science. Materials in Medicine
Jun JinYizao Wan

Abstract

Hydroxyapatite nanoparticles have been reported to exhibit potent anti-tumor effects in some cancer cells. In our previous study, we have successfully synthesized two types of hydroxyapatite nanoparticles, laminated hydroxyapatite (L-HAp) and laminated magnetic hydroxyapatite (LM-HAp). In this study, we wanted to investigate the effects of L-HAp and LM-HAp with various concentrations on human breast cancer MDA-MB-231 cells. Cell proliferation was assessed with a MTT colorimetric assay. Scratch and adhesion assays were used to detect the effects of these two materials on migration and adhesion. The expressions of integrin β1 and Akt were measured by Western blotting. Our results showed that L-HAp and LM-HAp had little cell cytotoxicity and significantly reduced cell mobility and adhesion. LM-HAp showed greater inhibitor ability on migration and adhesion of MDA-MB-231 cells. Moreover, results from western blotting showed that L-HAp and LM-HAp impacted the phosphorylation of integrin β1, but showed no regular impact on Akt. This study suggests that L-HAp and LM-HAp may be potential anti-tumor and delivery system for breast cancer therapy.

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Citations

Aug 13, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Vladimir Mulens-AriasDomingo F Barber
Apr 4, 2015·Journal of the Mechanical Behavior of Biomedical Materials·Yizao WanHonglin Luo
Oct 25, 2016·International Journal of Pharmaceutics·Honglin LuoYizao Wan
Jan 17, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Roxana Mayra GorojodMónica Lidia Kotler
Mar 28, 2021·Advances in Colloid and Interface Science·Adrianna BiedrzyckaUrban Margareta Hanna
Apr 5, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Zhihuan HuangHonglin Luo

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