Abstract
Immunological effects of polychlorinated biphenyls (PCBs) have been demonstrated in our laboratories with the peferential inhibition of lipopolysaccharide (LPS)-induced splenocyte proliferation by ortho-substituted PCB congeners. An investigation of the mechanism behind this immunotoxicity revealed an interruption in the progression of murine lymphocytes from G0/G1 into S phase by Aroclor 1242 and the di-ortho-substituted congener, 2,2'-chlorobiphenyl (CB), whereas, a non-ortho-substituted congener, 4,4'-CB, did not affect cell cycle progression. This interruption of cell cycle progression by 2,2'-CB and Aroclor 1242 was associated with a decreased expression of the cell cycle regulatory protein, cyclin D2, while expression was not affected by exposure to the non-ortho-substituted 4,4'-CB. These results suggest the preferential inhibition of LPS-induced splenocyte proliferation by ortho-substituted congeners is a result of a decreased expression of cyclin D2, which leads to an interruption in cell cycle progression. In addition, PCB mixtures with an increased percentage of chlorines in the ortho position following an environmentally occurring degradation process inhibited LPS-induced proliferation, interrupted cell cycle progre...Continue Reading
References
Apr 1, 1990·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·N I KerkvlietD R Buhler
Jul 1, 1990·Toxicology·D Davis, S Safe
Jul 1, 1989·Toxicology Letters·D Davis, S Safe
Nov 1, 1983·Cytometry·E H TateW Wharton
Mar 10, 1995·Science·K BrownU Siebenlist
Dec 1, 1995·Environmental Health Perspectives·K KrzystyniakM Fournier
Aug 1, 1996·The Journal of Experimental Medicine·N SolvasonM C Howard
Nov 1, 1996·Toxicology Letters·C HaderN H Seemayer
Oct 1, 1996·Molecular Immunology·S Reid, E C Snow
Jul 7, 1998·Toxicology and Applied Pharmacology·O A VoieF Fonnum
Jan 21, 2000·Mutagenesis·K G JensenA Onfelt
Mar 10, 2000·Mutation Research·P SánchezA Castaño
Apr 11, 2000·Bulletin of Environmental Contamination and Toxicology·J K WickliffeJ W Bickham
Jul 6, 2000·The Journal of Experimental Medicine·H OgataA Tarakhovsky
Aug 19, 2000·Archives of Environmental Contamination and Toxicology·T B MinhA Subramanian
Nov 18, 2000·Mutation Research·B BinkováR J Srám
Feb 13, 2001·Carcinogenesis·B MahadevanW M Baird
Jun 25, 2002·Toxicology and Applied Pharmacology·Bernhard HennigLarry W Robertson
May 28, 2003·Toxicology·L Ashley SmithwickPamela J Morris
Citations
Feb 7, 2008·Journal of Toxicology and Environmental Health. Part a·Chiharu MoriSylvain De Guise
Apr 26, 2005·Aquatic Toxicology·Luke R IwanowiczStephen D McCormick
Mar 24, 2010·Free Radical Biology & Medicine·Leena ChaudhuriPrabhat C Goswami
Mar 25, 2008·Environmental Research·Taeko TsunetaCarmen Grindatti