PMID: 2493243Jan 1, 1989Paper

The inhibition of tyrosinase by pyridinones

The Biochemical Journal
R C Hider, K Lerch

Abstract

3-Hydroxypyridine-4-ones have potential as orally active chelators of iron(III) and therefore may find application in the treatment of thalassaemia. An undesirable feature of these molecules is that they inhibit tyrosinase. We have established that alkyl substitution at position 2 in the aromatic ring minimizes interaction with tyrosinase and does so without appreciably influencing the affinity for iron(III).

Citations

Sep 22, 2006·Amino Acids·K Lalitha, S Rajendra Kulothungan
Feb 7, 2012·Chembiochem : a European Journal of Chemical Biology·Carole DuboisMarius Réglier
Jan 1, 1990·Annals of the New York Academy of Sciences·R C HiderE R Huehns
Jan 31, 2013·Chemistry : a European Journal·Constance BochotHélène Jamet
Feb 9, 2019·Journal of Enzyme Inhibition and Medicinal Chemistry·Samaneh ZolghadriAli Akbar Saboury
Dec 8, 2020·Chemistry : a European Journal·Elina BuitragoCatherine Belle
Jun 10, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Michael V GormallyCynthia R D Selassie
Dec 30, 2010·Journal of Medicinal Chemistry·Jennifer A JacobsenSeth M Cohen
Jul 11, 2000·Journal of Agricultural and Food Chemistry·S M SonC Y Lee

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