The inhibition/excitation ratio related to task-induced oscillatory modulations during a working memory task: A multtimodal-imaging study using MEG and MRS

NeuroImage
Yuichi TakeiMasato Fukuda

Abstract

Detailed studies on the association between neural oscillations and the neurotransmitters gamma-aminobutyric acid (GABA) and glutamate have been performed in vitro. In addition, recent functional magnetic resonance imaging studies have characterized these neurotransmitters in task-induced deactivation processes during a working memory (WM) task. However, few studies have investigated the relationship between these neurotransmitters and task-induced oscillatory changes in the human brain. Here, using combined magnetoencephalography (MEG) and magnetic resonance spectroscopy (MRS), we investigated the modulation of GABA and glutamate + glutamine (Glx) concentrations related to task-induced oscillations in neural activity during a WM task. We first acquired resting-state MRS and MEG data from 20 healthy male volunteers using the n-back task. Time-frequency analysis was employed to determine the power induced during the encoding and retention phases in perigenual anterior cingulate cortex (pg-ACC), mid-ACC, and occipital cortex (OC). Statistical analysis showed that increased WM load was associated with task-induced oscillatory modulations (TIOMs) of the theta-gamma band relative to the zero-back condition (TIOM0B) in each volume of...Continue Reading

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Citations

Dec 18, 2018·Human Brain Mapping·Frederick W CarverRichard Coppola
Apr 8, 2020·Frontiers in Human Neuroscience·Helene Gudi-MindermannBrigitte Röder
Sep 25, 2020·Royal Society Open Science·Vuong Truong, Niall W Duncan
Jun 10, 2019·Trends in Neuroscience and Education·Kanchna RamchandranNancy C Andreasen
Jul 27, 2021·Journal of Alzheimer's Disease : JAD·Anshika GoelPravat K Mandal

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