PMID: 4302725Jan 1, 1969Paper

The inhibitory action of noradrenaline and adrenaline on acetylcholine output by guinea-pig ileum longitudinal muscle strip

British Journal of Pharmacology
W D PATON, E S Vizi

Abstract

1. Noradrenaline and adrenaline reduce the output of acetylcholine by the guinea-pig ileum longitudinal strip by up to 80%, both in resting conditions and after stimulation. The effect is graded with dose, and is detectable with noradrenaline 2 x 10(-7) g/ml. Adrenaline is approximately 4 times as active as noradrenaline, and its action after being washed out is more persistent.2. If resting output is high, both amines have a proportionately greater effect and their action, as dosage is increased, is to reduce resting output to a basal level, relatively constant from strip to strip, of about 10 ng/g/min.3. With stimulation, the effect of the amine is greater at low frequencies, when the output per volley is high, than at high frequencies. The effect is reduced by increasing the number of shocks delivered. There thus appears to be a basal output per volley, of the order of 1-2 ng/g/volley, which can be reached either by relatively rapid stimulation, by prolonged stimulation, or by treatment with these amines.4. If noradrenaline is applied during continued stimulation at 40/min, the depression of acetylcholine output during its presence is followed by an augmented output when the drug is withdrawn. The magnitude of this "overshoo...Continue Reading

References

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Citations

Jul 29, 1998·Journal of Peptide Science : an Official Publication of the European Peptide Society·F SebestyénA Furka
Jul 1, 1977·Journal of Clinical Pharmacology·F LechinF Peña
Oct 1, 1979·Journal of Clinical Pharmacology·F Lechin, B Van Der Dijs
Jan 1, 1970·Histochemie. Histochemistry. Histochimie·J B Furness
Sep 22, 1969·Zeitschrift für Zellforschung und mikroskopische Anatomie·H G Baumgarten, W Lange
Oct 1, 1980·Naunyn-Schmiedeberg's Archives of Pharmacology·M AndréjakH Schmitt
Sep 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·R E Loiacono, D F Story
Oct 1, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·G BertacciniJ Zseli
Oct 6, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·M ToniniA Crema
Sep 8, 1973·Naunyn-Schmiedeberg's Archives of Pharmacology·A Heise, G Kroneberg
Apr 1, 1983·Naunyn-Schmiedeberg's Archives of Pharmacology·R A LefebvreM G Bogaert
Dec 1, 1985·Naunyn-Schmiedeberg's Archives of Pharmacology·K J Broadley, P F Grassby
Jan 1, 1972·Naunyn-Schmiedeberg's Archives of Pharmacology·K Starke
Jan 1, 1972·Naunyn-Schmiedeberg's Archives of Pharmacology·J KnollE S Vizi
May 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·V BauerH Kuriyama
Nov 1, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·H Kilbinger, I Wessler
Dec 19, 1973·Naunyn-Schmiedeberg's Archives of Pharmacology·F Takenaka, T Ishihara
Mar 14, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·M A Enero, B Q Saidman
Jun 1, 1981·Cellular and Molecular Neurobiology·C FlickerJ A Hobson
Jan 1, 1984·Neir̆ofiziologiia = Neurophysiology·I A Vladimirova, M F Shuba
Dec 1, 1972·Journal of Neurocytology·G Gabella
Jan 1, 1979·Journal of Neural Transmission·V Adám-ViziI Horváth
Jan 1, 1969·Naunyn-Schmiedebergs Archiv Für Pharmakologie·K Löffelholz, E Muscholl
Jan 1, 1978·Journal of Neural Transmission·V Adám-Vizi, E S Vizi
Dec 1, 1982·Agents and Actions·M de Lourdes Arruzazabala, R G Alvarez
Nov 1, 1970·Canadian Anaesthetists' Society Journal·F J Rathbun, J T Hamilton
May 25, 2006·Naunyn-Schmiedeberg's Archives of Pharmacology·Rita BenkóLorand Barthó

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