The inhibitory effect of clindamycin on Lactobacillus in vitro

Infectious Diseases in Obstetrics and Gynecology
A A AroutchevaSebastian Faro

Abstract

To evaluate the in vitro effect of varying concentrations of clindamycin on Lactobocillus spp. Concentrations of clindamycin ranging from 1.95-20,000 microg/ml were studied for their effect on the growth of six strains of Lactobacillus. Clindamycin concentrations between 1.95-31.25 microg/ml had no statistically significant effect on growth of lactobacilli (p > 0.05). Concentrations 125 and 250 microg/ml had a bacteriostatic effect. The mean minimum inhibitory concentration (MIC) for studied Lactobacillus strains was determined as 1,000 microg/ml. High concentrations of clindamycin achieved in the vagina by intravaginal application might be inhibitory for Lactobacillus.

Citations

Aug 30, 2005·Infectious Diseases in Obstetrics and Gynecology·Jie LiMichael L Chikindas
Sep 8, 2005·Journal of Clinical Microbiology·M N AustinS L Hillier
Oct 1, 2008·BJOG : an International Journal of Obstetrics and Gynaecology·L Petricevic, A Witt
May 2, 2006·American Journal of Obstetrics and Gynecology·Paul NyirjesyJames L Joffrion
Oct 2, 2012·Infectious Diseases in Obstetrics and Gynecology·Yevgeniy TurovskiyMichael L Chikindas

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.