The inhibitory effect of Cordycepin on the proliferation of cisplatin-resistant A549 lung cancer cells

Biochemical and Biophysical Research Communications
Seong Hyeok Cho, In-Cheol Kang

Abstract

The goal of this study is to determine the anti-cancer mechanism of Cordycepin in A549 Cisplatin-Resistance (CR) lung cancer cells. Cordycepin inhibited the viability of A549CR cells in a dose-dependent manner. The cell inhibition was due to induction of apoptosis in the cells treated with Cordycepin by activation of caspase -3, -8 and -9 activities. The cell cycle analysis showed that accumulation of Sub G1 was observed in Cordycepin-treated with A549CR lung cancer cells. Based on the data of expression profile analysis of cell signaling proteins using IPS-FPAA, H-Ras was down-regulated in Cordycepin-treated A549CR cells. Collectively, anti-proliferative function of Cordycepin was due to stimulation of the cell apoptosis and the cell cycle arrest via caspases activation and down-regulation of H-Ras.

Citations

Aug 14, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tran Ngoc QuyRolf Teschke
Oct 3, 2018·Current Medicinal Chemistry·Md Asaduzzaman Khan, Mousumi Tania
Nov 12, 2020·International Journal of Molecular Sciences·Ming-Min ChangBu-Miin Huang

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