The inhibitory effect of heme on heme formation in vivo: possible mechanism for the regulation of hemoglobin synthesis

The Journal of Clinical Investigation
R C Gallo

Abstract

1) The effect of hemin on heme synthesis was studied in vivo. Heme synthesis was measured by determining red cell (59)Fe uptake and glycine-2-(14)C incorporation into red cell hemin in normal CF(1) female mice.2) Both bovine and human hemin significantly decreased red cell (59)Fe uptake 48, 72, and 96 hours after hemin injection.3) Glycine-2-(14)C incorporation into red cell hemin was decreased to 50% of control values after the administration of hemin (90 mumoles per kg).4) There was no significant difference between the plasma iron of mice injected with hemin and the values in control groups.5) Protoporphyrin decreased the inhibitory effect of hemin on red cell (59)Fe uptake by 64%.6) There was no measurable effect of delta-aminolevulinic acid on hemin inhibition of red cell (59)Fe uptake.7) Data are presented to show that the effect of hemin is not by a dilution mechanism nor by a decrease in red cell maturation and subsequent release of reticulocytes into the peripheral blood. The findings are discussed in regard to the possible site of a negative feedback control of heme synthesis by heme.

References

Mar 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·A I GrayzelI M London
Jun 1, 1965·Archives of Biochemistry and Biophysics·C L Hammel, S P Bessman
Jan 1, 1953·Scandinavian Journal of Clinical and Laboratory Investigation·L ERIKSEN
Nov 1, 1957·Biochimica Et Biophysica Acta·R F LABBE, G NISHIDA
Oct 1, 1959·Biochimica Et Biophysica Acta·F W TEALE
Apr 1, 1964·Journal of the Air Pollution Control Association·R LAWRENCEL A RIPPERTON
Jan 18, 1965·Biochemical and Biophysical Research Communications·G P BRUNS, I M LONDON
Jan 18, 1965·Biochemical and Biophysical Research Communications·D KARIBIAN, I M LONDON
May 3, 1965·Biochemical and Biophysical Research Communications·H S WAXMAN, M RABINOVITZ
Aug 1, 1962·The Journal of Clinical Investigation·J D OSTROWR SCHMID

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Citations

Aug 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·T M CoxI M London
Nov 13, 2002·Journal of Hematotherapy & Stem Cell Research·Robert C Gallo
Sep 12, 2015·The Journal of Toxicological Sciences·Yasuhiro ShinkaiYoshito Kumagai
Aug 1, 1986·Journal of the American Geriatrics Society·D L Marcus, M L Freedman
May 1, 1975·Scandinavian Journal of Haematology·R Lindemann

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